NQTrp
Modify Date: 2024-01-31 12:05:38
NQTrp structure
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Common Name | NQTrp | ||
|---|---|---|---|---|
| CAS Number | 185351-19-3 | Molecular Weight | 360.36300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H16N2O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of NQTrpNQTrp, an aromatic naphthoquinone-tryptophan hybrid molecule, an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects. NQTrp inhibits the in vitro aggregation of hexapeptide (41GCWMLY46 within the N-terminus of γD-crystallin) as well as full-length γD-crystallin[1]. |
| Name | (2S)-2-[(1,4-dioxonaphthalen-2-yl)amino]-3-(1H-indol-3-yl)propanoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | NQTrp, an aromatic naphthoquinone-tryptophan hybrid molecule, an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects. NQTrp inhibits the in vitro aggregation of hexapeptide (41GCWMLY46 within the N-terminus of γD-crystallin) as well as full-length γD-crystallin[1]. |
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| Related Catalog | |
| In Vitro | In TEM analysis, GDC6 peptide fibrils (50 μM) in the presence of NQTrp 5:1, 1:1, 1:5 ratio (GDC6: NQTrp). NQTrp effectively inhibits the fibrillation of the GDC6 peptide (50 μM) in a dose-dependent manner and prevents the formation of elongated amyloid fibrils[1]. NQTrp has no toxic effect toward retinal cell culture and reduces the cytotoxicity induced by aggregates of the hexapeptide(IC50=70 μM) in ARPE-19 cells[1]. |
| References |
| Molecular Formula | C21H16N2O4 |
|---|---|
| Molecular Weight | 360.36300 |
| Exact Mass | 360.11100 |
| PSA | 99.26000 |
| LogP | 3.10720 |
| InChIKey | DZZUYZXINNHEGM-SFHVURJKSA-N |
| SMILES | O=C1C=C(NC(Cc2c[nH]c3ccccc23)C(=O)O)C(=O)c2ccccc21 |
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Combined experimental and simulation studies suggest a revised mode of action of the anti-Alzheimer disease drug NQ-Trp.
Chemistry 21 , 12657-66, (2015) Inhibition of the aggregation of the monomeric peptide β-amyloid (Aβ) into oligomers is a widely studied therapeutic approach in Alzheimer's disease (AD). Many small molecules have been reported to wo... |
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Naphthoquinone-Tryptophan Hybrid Inhibits Aggregation of the Tau-Derived Peptide PHF6 and Reduces Neurotoxicity.
J. Alzheimers Dis. 51 , 165-78, (2016) Tauopathies, such as Alzheimer's disease (AD), are a group of disorders characterized neuropathologically by intracellular toxic accumulations of abnormal protein aggregates formed by misfolding of th... |
| L-Tryptophan,N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl) |
| TRY001 |