Isoferulic acid

Isoferulic acid Structure
Isoferulic acid structure
Common Name Isoferulic acid
CAS Number 537-73-5 Molecular Weight 194.184
Density 1.3±0.1 g/cm3 Boiling Point 410.2±35.0 °C at 760 mmHg
Molecular Formula C10H10O4 Melting Point 230 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 167.6±19.4 °C
Symbol GHS07
GHS07
Signal Word Warning

A metabolite profiling approach to identify biomarkers of flavonoid intake in humans.

J. Nucl. Med. 139 , 2309-14, (2009)

Flavonoids are phytochemicals that are widespread in the human diet. Despite limitations in their bioavailability, experimental and epidemiological data suggest health benefits of flavonoid consumption. Valid biomarkers of flavonoid intake may be useful for e...

Development of a targeted method for twenty-three metabolites related to polyphenol gut microbial metabolism in biological samples, using SPE and UHPLC-ESI-MS/MS.

Talanta 128 , 221-30, (2014)

An increasing number of studies have concerned the profiling of polyphenol microbial metabolites, especially in urine or plasma, but only a few have regarded their accurate quantification. This study reports on a new ultra-performance liquid chromatography ta...

Ion-pairing reversed-phase liquid chromatography fractionation in combination with isotope labeling reversed-phase liquid chromatography–mass spectrometry for comprehensive metabolome profiling

J. Chromatogr. A. 1218(23) , 3689-94, (2011)

We report a novel two-dimensional (2D) separation strategy aimed at improving the detectability of liquid chromatography mass spectrometry (LC–MS) for metabolome analysis. It is based on the use of ion-pairing (IP) reversed-phase (RP) LC as the first dimensio...

Fate of microbial metabolites of dietary polyphenols in rats: is the brain their target destination?

ACS Chem. Neurosci. 6 , 1341-52, (2015)

Different polyphenol compounds are ingested when consuming a serving of fruits rich in polyphenols, spanning from one-phenol hydroxybenzoic acid to more complex polymeric compounds. Only a minor quantity of the polyphenols (5-10%) is absorbed. The remainder r...

Combined experimental and computational investigation of the absorption spectra of E- and Z-cinnamic acids in solution: The peculiarity of Z-cinnamics.

J. Photochem. Photobiol. B, Biol. 148 , 128-35, (2015)

Cinnamic acids are present in all kinds of plant tissues and hence in herbs and derived medicines, cosmetics and foods. The interest in their role in plants and their therapeutic applications has grown exponentially. Because of their molecular structure they ...

The metabolism of dietary polyphenols and the relevance to circulating levels of conjugated metabolites.

Free Radic. Res. 36(11) , 1229-41, (2002)

Berry extracts rich in anthocyanins have been linked to protective effects including the modulation of age-related neurological dysfunction and the improvement of the resistance of red blood cells against oxidative stress in vitro. In this study the bioavaila...

Identification of tyrosinase inhibitors from Marrubium velutinum and Marrubium cylleneum.

Bioorg. Med. Chem. 15 , 2708-14, (2007)

Tyrosinase is a key enzyme in the production of melanins in plants and animals. Forty-five secondary metabolites isolated from Marrubium velutinum and Marrubium cylleneum belonging to the classes of flavonoids, phenylethanoid glycosides, phenolic acids and li...

Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells.

Bioorg. Med. Chem. Lett. 22 , 154-63, (2012)

The binding between the estrogen receptor α (ER-α) and a variety of compounds in traditional Chinese formulae, Si-Wu-Tang (SWT) series decoctions, was studied using a stably-transfected human breast cancer cell line (MVLN). In 38 compounds tested from SWT ser...

[Study on chemical constituents from ethyl acetate extract of Myricaria bracteata].

Zhongguo Zhong Yao Za Zhi 36(8) , 1019-23, (2011)

To study the chemical constituents from the ethyl acetate extract of Myricaria bracteata.The chemical constituents were isolated and purified by chromatographic techniques, and their structures were identified by physical characters and spectroscopic analysis...

Evaluation of antioxidant activity of isoferulic acid in vitro.

Yakugaku Zasshi 126(3) , 173-7, (2006)

Isoferulic acid (3-hydroxy-4-methoxycinnamic acid, IFA), the isomer of ferulic acid (4-hydroxy-3-methoxycinnamic acid), is a rare phenolic acid occurring in Rhizoma Cimicifugae. Unlike ferulic acid, which has been well investigated, the antioxidant activity o...