537-73-5

537-73-5 structure

Name: Isoferulic acid
Chemical Name: 3-Hydroxy-4-methoxycinnamic acid
CAS Number: 537-73-5
Molecular Formula: C₁₀H₁₀O₄
Molecular Weight: 194.184
Catalog: Flavors and spices Synthetic spice Aromatic cinnamic acid, esters and derivatives
Create Date: 2018-05-09 08:00:00
Modify Date: 2025-08-21 10:00:29
3-Hydroxy-4-methoxycinnamic acid (Isoferulic acid) is a cinnamic acid derivative that has antidiabetic activity. 3-Hydroxy-4-methoxycinnamic acid binds to and activates α1-adrenergic receptors (IC50=1.4 µM) to enhance secretion of β-endorphin (EC50=52.2 nM) and increase glucose use.

Name	3-Hydroxy-4-methoxycinnamic acid
Synonyms	3'-hydroxy-4'-methoxy cinnamic acid Hesperitinic acid trans-Isoferulic acid 2-Propenoic acid, 3-(3-hydroxy-4-methoxyphenyl)-, (2E)- RARECHEM BK HW 0093 trans-3-hydroxy-4-methoxycinnamic acid 3-Hydroxy-4-MethoxycinnaMic Acid 3-(3-Hydroxy-4-methoxyphenyl)acrylic acid 3-Hydroxy-4-methoxycinnamic Isoferulic acid HESPERETINIC ACID Isoferulate MFCD00004391 EINECS 208-676-0 Isoferulic Caffeic acid 4-methyl ether (2E)-3-(3-Hydroxy-4-methoxyphenyl)acrylic acid 3-(3-Hydroxy-4-methoxyphenyl)-2-propenoic acid Hesperetic acid (2E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoic acid 3-hydroxy-4-methoxy-Cinnamic acid

Description	3-Hydroxy-4-methoxycinnamic acid (Isoferulic acid) is a cinnamic acid derivative that has antidiabetic activity. 3-Hydroxy-4-methoxycinnamic acid binds to and activates α1-adrenergic receptors (IC50=1.4 µM) to enhance secretion of β-endorphin (EC50=52.2 nM) and increase glucose use.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Metabolic Disease Natural Products >> Phenylpropanoids
References	[1]. Liu IM, et al. Mediation of beta-endorphin by isoferulic acid to lower plasma glucose in streptozotocin-induced diabetic rats. J Pharmacol Exp Ther. 2003 Dec;307(3):1196-204.

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 95,539,1975

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 95,539,1975

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	UD3365400
HS Code	29189090

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%