BioBioPha
China
Product Name: Hesperidin
Price: ￥Inquiry/50mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Hesperidin
Price: ￥88.0/20mg ￥398.0/100g ￥138.0/25g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Hesperidin
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Xi'an Reach Pharmaceutical Technology Co.,Ltd.
China
Product Name: Hesperidine
Price: ￥Inquiry/1kg
Purity: 96.0%
Stocking Period: Inquiry
Contact: Grace

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Hesperidin 97%
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

520-26-3

520-26-3 structure

Name: Hesperidin
Chemical Name: hesperidin
CAS Number: 520-26-3
Molecular Formula: C₂₈H₃₄O₁₅
Molecular Weight: 610.561
Catalog: API Circulatory system medication Regulating blood lipids
Create Date: 2018-02-08 08:00:00
Modify Date: 2024-01-02 12:26:56
Hesperidin (HP) is a bioflavonoid that plays a role in plant defense and is abundant in citrus species, such as grapefruit, lemon and orange. Hesperidin is used effectively as a supplemental agent in complementary therapy protocols, since it possesses biological and pharmacological properties as an effective antioxidant, anti-inflammatory, anti-carcinogenic, and anti-hypertensive agent with lipid-lowering activity[1]IC50: hesperidin (IC50=116.68μmo/L))[4]in vitro: hesperidin and linarin are two of the main constituent of Valeriana's extract exhibiting a high affinity to KATP channel, which are related to the control of Ca++ concentration and release of GABA in synaptic nerve terminal, mainly on cells of SN[2]in vivo: Hesperidin was dissolved in 1% carboxymethyl cellulose (CMC) and administered orally at a dose of 50 mg/kg for 10 consecutive days. In the control group, rats were treated with the corn oil and 1% CMC vehicle.[1]

Name	hesperidin
Synonyms	usafcf-3 Hesperetin 7-rhamnoglucoside,Hesperitin-7-rutinoside VITAMIN P Hespeidin Hespiridin Hesperiden Neobiletin cirantin MFCD00075663 Hesperetin7-rutinoside Cirontin Hesperidoside Hesperetin7-rhamnoglucoside Hesperidin EINECS 208-288-1

Description	Hesperidin (HP) is a bioflavonoid that plays a role in plant defense and is abundant in citrus species, such as grapefruit, lemon and orange. Hesperidin is used effectively as a supplemental agent in complementary therapy protocols, since it possesses biological and pharmacological properties as an effective antioxidant, anti-inflammatory, anti-carcinogenic, and anti-hypertensive agent with lipid-lowering activity[1]IC50: hesperidin (IC50=116.68μmo/L))[4]in vitro: hesperidin and linarin are two of the main constituent of Valeriana's extract exhibiting a high affinity to KATP channel, which are related to the control of Ca++ concentration and release of GABA in synaptic nerve terminal, mainly on cells of SN[2]in vivo: Hesperidin was dissolved in 1% carboxymethyl cellulose (CMC) and administered orally at a dose of 50 mg/kg for 10 consecutive days. In the control group, rats were treated with the corn oil and 1% CMC vehicle.[1]
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Natural Products >> Flavonoids Research Areas >> Cancer
References	[1]. Asli Cetin, Ali Otlu et al. Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachloride administration in Wistar rats. Arch Med Sci, 2016 Jun 1, 12(3): 486-493. [2]. Gesivaldo Santos, Bruno Andrade et al. SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson. Front Aging Neurosci, 2016, 8: 97. [3]. Jin Zhang, Jing Gao et al. Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest. BMC Cancer, 2015, 15: 682. [4]. Cetin A, Otlu A, ea al. Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachlorideadministration in Wistar rats. Arch Med Sci, 2016 Jun 1, 12(3):486-93.

Density	1.7±0.1 g/cm3
Boiling Point	930.1±65.0 °C at 760 mmHg
Melting Point	250-255 °C (dec.)(lit.)
Molecular Formula	C₂₈H₃₄O₁₅
Molecular Weight	610.561
Flash Point	305.5±27.8 °C
Exact Mass	610.189758
PSA	234.29000
LogP	1.78
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.695

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MK6650000

CHEMICAL NAME :: Hesperidin

CAS REGISTRY NUMBER :: 520-26-3

BEILSTEIN REFERENCE NO. :: 0075140

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C28-H34-O15

MOLECULAR WEIGHT :: 610.62

WISWESSER LINE NOTATION :: T66 BO EVT&J CR CQ DO1& GQ IO- BT6OTJ CQ DQ EQ F1O- BT6OTJ CQ DQ EQ F1 GLUCO RHAMNO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84694 No. of Facilities: 156 (estimated) No. of Industries: 2 No. of Occupations: 10 No. of Employees: 8654 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R22
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	MK6650000

161713-86-6

520-26-3

Literature: Yamada, Mika; Tanabe, Fujimi; Arai, Norie; Mitsuzumi, Hitoshi; Miwa, Yoshikatsu; Kubota, Michio; Chaen, Hiroto; Kibata, Masayoshi Bioscience, Biotechnology and Biochemistry, 2006 , vol. 70, # 6 p. 1386 - 1394

161713-86-6

520-26-3