Nitecapone
Nitecapone structure
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Common Name | Nitecapone | ||
|---|---|---|---|---|
| CAS Number | 116313-94-1 | Molecular Weight | 265.21900 | |
| Density | 1.451g/cm3 | Boiling Point | 495.3ºC at 760 mmHg | |
| Molecular Formula | C12H11NO6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 211.6ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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D1-like dopamine receptor activation and natriuresis by nitrocatechol COMT inhibitors.
Kidney Int. 59(5) , 1683-94, (2001) In recent years, several nitrocatechol derivatives (tolcapone, entacapone, and nitecapone) have been developed and found to be highly selective and potent inhibitors of catechol-O-methyltransferase (COMT). More recently, natriuretic properties were described ... |
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Extending levodopa action: COMT inhibition.
Neurology 50(6 Suppl 6) , S27-32; discussion S44-8, (1998) Degradation of levodopa in the periphery is known to be associated with motor fluctuations and dyskinesia in Parkinson's disease (PD) patients. The enzyme catechol-O-methyltransferase (COMT) is responsible for much of this degradation. Therefore, inhibiting C... |
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The Helicobacter felis mouse model in assessing anti-Helicobacter therapies and gastric mucosal prostaglandin E2 levels.
Scand. J. Gastroenterol. 31(4) , 334-8, (1996) The aims of the present study were to assess the usefulness of the Helicobacter felis mouse model in the evaluation of antimicrobial therapies and the effect of Helicobacter infection on gastric mucosal prostaglandin E2 release.Barrier-maintained BALB/c mice ... |
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Nitecapone and selegiline as effective adjuncts to L-DOPA in reserpine-induced catatonia in mice.
Methods Find. Exp. Clin. Pharmacol. 24(1) , 23-9, (2002) Reserpine-induced catatonia is a widely accepted animal model of Parkinson's disease. In the present study, reserpine (5 mg/kg i.p.) and alpha-methylpara-tyrosine (AMPT) (200 mg/kg i.p.) induced catatonia in mice 20 h and 1 h before the experiment, respective... |
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Dopamine is metabolised by different enzymes along the rat nephron.
Pflugers Arch. 450(3) , 185-91, (2005) The purpose of this study was to determine the basal levels of dopamine (DA) and to examine the enzymes involved in DA metabolism in different microdissected nephron segments from rat kidneys. Segments were incubated with DA (50 nM) or DA plus monoamine oxida... |
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The effect of nitecapone on early graft function in experimental single lung transplantation.
Scand. Cardiovasc. J. 34(4) , 415-20, (2000) Nitecapone is an antioxidant molecule which has been shown to protect the heart against ischemia-reperfusion injury. We investigated whether a similar effect could be detected on lung graft preservation in a porcine model of single lung transplantation. Donor... |
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Investigation of gastroprotective compounds at subcellular level in isolated gastric mucosal cells.
Am. J. Physiol. Gastrointest. Liver Physiol. 279(6) , G1201-8, (2000) We tested the hypothesis that recognized gastroprotective agents exert direct protection against ethanol-induced injury in isolated rat gastric mucosal cells in vitro. If protection exists, we also wanted to identify subcellular targets in the reversible and/... |
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Dopamine-induced recruitment of dopamine D1 receptors to the plasma membrane.
Proc. Natl. Acad. Sci. U. S. A. 95(10) , 5573-8, (1998) The recruitment of G protein-coupled receptors from the cytoplasm to the plasma membrane generally is believed to be a constitutive process. We show here by the use of both confocal microscopy and subcellular fractionation that, for at least one such receptor... |
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Graphical analysis of 6-fluoro-L-dopa trapping: effect of inhibition of catechol-O-methyltransferase.
J. Nucl. Med. 38(10) , 1568-74, (1997) Graphical methods to analyze tracer time-course data allow reliable quantitation of the rate of incorporation of tracer from plasma into a "trapped" kinetic component, even when the details of the kinetic model are unknown. Applications of the method over lon... |
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Combined antioxidant and COMT inhibitor treatment reverses renal abnormalities in diabetic rats.
Diabetes 49(8) , 1381-9, (2000) The development and progression of diabetic nephropathy is dependent on glucose homeostasis and many other contributing factors. In the present study, we examined the effect of nitecapone, an inhibitor of the dopamine-metabolizing enzyme catechol-O-methyl tra... |