N-Phenylmaleimide
N-Phenylmaleimide structure
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Common Name | N-Phenylmaleimide | ||
|---|---|---|---|---|
| CAS Number | 941-69-5 | Molecular Weight | 173.168 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 299.3±9.0 °C at 760 mmHg | |
| Molecular Formula | C10H7NO2 | Melting Point | 85-87 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 136.8±11.1 °C | |
| Symbol |
GHS05, GHS06, GHS09 |
Signal Word | Danger | |
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Michael addition/pericyclization/rearrangement--a multicomponent strategy for the synthesis of substituted resorcinols.
Org. Biomol. Chem. 10(31) , 6388-94, (2012) The combination of methyl 3,7-dioxo-2-diazo-4-octenoate from the zinc triflate catalyzed Mukaiyama-Michael reaction of methyl 3-tert-butylsilyloxy-2-diazobutenoate and 4-methoxy-3-buten-2-one with Michael acceptors (methyl vinyl ketone, N-phenylmaleimide, β-n... |
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Chemical modification of milk xanthine oxidase with different modifiers.
Prep Biochem Biotechnol. 33(3) , 173-87, (2003) Xanthine oxidase (XO), purified from buttermilk was subjected to modification with N-phenylmaleimide, p-toluene-sulfonyl chloride, and 2-mercaptobenzimidazole. Spectrophotometric monitoring of the enzyme before and after treatment with these modifiers are pre... |
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Behavior of N-phenylmaleimide- and p-phenylenedimaleimide-reacted muscle crossbridge heads.
Biochim. Biophys. Acta 1367(1-3) , 127-33, (1998) The finding of Barnett et al. (Biophys. J. 61 (1992) 358) that NPM-reacted crossbridge heads do not bind strongly to actin in rigor solution is not easily interpreted in terms of the solution studies of Xie and Schoenberg (Biochemistry 37 (1998) 8048) who fou... |
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Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors.
J. Med. Chem. 52 , 7410-20, (2009) The endocannabinoid 2-arachidonoylglycerol (2-AG) plays a major role in many physiological processes, and its action is quickly terminated via enzymatic hydrolysis catalyzed by monoglyceride lipase (MGL). Regulating its endogenous level could offer therapeuti... |
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Is SH1-SH2-cross-linked myosin subfragment 1 a structural analog of the weakly-bound state of myosin?
Biophys. J. 79(1) , 460-7, (2000) Myosin subfragment 1 (S1) with SH1 (Cys(707)) and SH2 (Cys(697)) groups cross-linked by p-phenylenedimaleimide (pPDM-S1) is thought to be an analog of the weakly bound states of myosin bound to actin. The structural properties of pPDM-S1 were compared in this... |
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Antifungal, cytotoxic and SAR studies of a series of N-alkyl, N-aryl and N-alkylphenyl-1,4-pyrrolediones and related compounds.
Bioorg. Med. Chem. 19 , 2823-34, (2011) The synthesis, in vitro evaluation and SAR studies of 67 maleimides and derivatives acting as antifungal agents are reported. A detailed SAR study supported by theoretical calculations led us to determine that: an intact maleimido ring appears to be necessary... |
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N-Phenyl and N-phenylalkyl-maleimides acting against Candida spp.: time-to-kill, stability, interaction with maleamic acids.
Bioorg. Med. Chem. 16 , 560-8, (2008) N-Phenyl and N-phenylalkyl maleimides (alkyl chain=(CH(2))n; n=0-4) and their respective open derivatives (maleamic acids) were evaluated against Candida spp. with the microbroth dilution method following the guidelines of CLSI (formely NCCLS). MIC values of ... |
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Glutathione-dependent conversion of N-ethylmaleimide to the maleamic acid by Escherichia coli: an intracellular detoxification process.
Appl. Environ. Microbiol. 66(4) , 1393-9, (2000) The electrophile N-ethylmaleimide (NEM) elicits rapid K(+) efflux from Escherichia coli cells consequent upon reaction with cytoplasmic glutathione to form an adduct, N-ethylsuccinimido-S-glutathione (ESG) that is a strong activator of the KefB and KefC gluta... |
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Diastereoselective intermolecular ene reactions: synthesis of 4,5,6,7-tetrahydro-1H-benzo[d]imidazoles.
Org. Biomol. Chem. 10(33) , 6649-55, (2012) The Diels-Alder cycloadducts of 4-vinylimidazoles and N-phenylmaleimide are shown to undergo facile intermolecular ene reactions. Overall the reaction of three simple molecules (a diene, a dienophile and an enophile) in a two-step process gives 4,5,6,7-tetrah... |
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Visible light may directly induce nuclear DNA damage triggering the death pathway in RGC-5 cells.
Mol. Vis. 17 , 3279-89, (2011) Visible light has been previously demonstrated to induce retinal ganglion cell (RGC)-5 cell death through the mitochondrial pathway. The present study was designed to determine whether visible light might also directly trigger the death pathway by damaging nu... |