1-Phenylpiperazine
1-Phenylpiperazine structure
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Common Name | 1-Phenylpiperazine | ||
|---|---|---|---|---|
| CAS Number | 92-54-6 | Molecular Weight | 162.232 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 287.2±15.0 °C at 760 mmHg | |
| Molecular Formula | C10H14N2 | Melting Point | 18.8 °C | |
| MSDS | Chinese USA | Flash Point | 138.3±11.4 °C | |
| Symbol |
GHS05, GHS06 |
Signal Word | Danger | |
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Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabilizer 4-[3-(methylsulfonyl)phenyl]-1-propylpiperidine (huntexil, pridopidine, ACR16).
J. Med. Chem. 53(6) , 2510-20, (2010) Modification of the partial dopamine type 2 receptor (D(2)) agonist 3-(1-benzylpiperidin-4-yl)phenol (9a) generated a series of novel functional D(2) antagonists with fast-off kinetic properties. A representative of this series, pridopidine (4-[3-(methylsulfo... |
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Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.
J. Med. Chem. 52(15) , 4923-35, (2009) Assembling phenylpiperazines with 7a-azaindole via different spacer elements, we developed subtype selective dopamine receptor ligands of types 1a,c, 2a, and 3a preferentially interacting with D4, D2, and D3, respectively. To complete this set, the methylthio... |
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Analysis of phenylpiperazine-like stimulants in human hair as trimethylsilyl derivatives by gas chromatography-mass spectrometry.
J. Chromatogr. A. 1217(40) , 6274-80, (2010) A simple and sensitive procedure, using p-tolylpiperazine (pTP) as internal standard (IS), has been developed and validated for the qualitative and quantitative analysis of 1-(3-trifuoromethylphenyl)piperazine (TFMPP), 1-(3-chlorophenyl)piperazine (mCPP) and ... |
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Sleep deprivation differentially affects dopamine receptor subtypes in mouse striatum.
Neuroreport 22(10) , 489-93, (2011) The effects of sleep deprivation on dopaminergic systems remain elusive, in part due to the lack of selective ligands for dopamine receptor subtypes. We examined D1, D2, and D3 receptor density in the mouse brain after sleep deprivation by receptor autoradiog... |
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Search for influence of spatial properties on affinity at α1-adrenoceptor subtypes for phenylpiperazine derivatives of phenytoin.
Bioorg. Med. Chem. Lett. 20(20) , 6152-6, (2010) A series of phenylpiperazine derivatives of phenytoin was evaluated for their affinity at α(1)-adrenoceptor subtypes in functional bioassays (rat tail artery: α(1A) and/or α(1B); guinea pig spleen: α(1B); rat aorta: α(1D)). The most potent compounds at α(1A)-... |
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DNA-binding, spectroscopic and antimicrobial studies of palladium(II) complexes containing 2,2'-bipyridine and 1-phenylpiperazine.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 96 , 586-93, (2012) With the purpose of evaluating the ability of Pd(II) complex to interact with DNA molecule as the main biological target, two new complexes [Pd(bpy)(OH(2))(2)] (1) and [Pd(Phenpip)(OH(2))(2)] (2), where (bpy=2,2'-bipyridine; Phenpip=1-phenylpiperazine), have ... |
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Serotonergic neurotransmission mediates hypothermia induced by the N-phenylpiperazine antipsychotic prototypes LASSBio-579 and LASSBio-581.
Pharmacol. Biochem. Behav. 89(1) , 23-30, (2008) Previous studies have demonstrated that LASSBio-579 and LASSBio-581, two N-phenylpiperazine derivatives designed for the treatment of schizophrenia, are presynaptic dopamine D(2) receptor agonists that induce a hypothermic effect in mice that is not mediated ... |
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[(18)F]-labeled 2-methoxyphenylpiperazine derivative as a potential brain positron emission tomography imaging agent.
Appl. Radiat. Isot. 67(11) , 2013-8, (2009) This study reports the synthesis and characterization of N-(3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl-4-[(18)F]fluorobenzamide ([(18)F]MPP3F). The total reaction time for [(18)F]MPP3F, including final high-performance liquid chromatography purification, was... |
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Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases.
Bioorg. Med. Chem. 17 , 4448-58, (2009) A series of phenylpiperazine-methyl-substituted 1H-pyrrolo[2,3-c]pyridine, imidazo[1,2-c]-, pyrrolo[2,3-d]- and pyrrolo[3,2-d]pyrimidines were prepared as selective dopamine D4-ligands. The pyrrolo[2,3-d]pyrimidine derivatives 12d (K(i)=1,9 nM) and 34 d (K(i)... |
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Transformation of N-phenylpiperazine by mixed cultures from a municipal wastewater treatment plant.
Appl. Environ. Microbiol. 74(19) , 6147-50, (2008) Samples from a wastewater treatment plant were used as inocula for mixed cultures dosed with N-phenylpiperazine (NPP), a model compound containing the piperazine ring found in many fluoroquinolones. Chemical analyses showed that NPP (50 mg liter(-1)) disappea... |