1-Phenylpiperazine

Modify Date: 2025-09-29 17:35:32

1-Phenylpiperazine structure	Common Name	1-Phenylpiperazine
	CAS Number	92-54-6	Molecular Weight	162.232
	Density	1.0±0.1 g/cm3	Boiling Point	287.2±15.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₄N₂	Melting Point	18.8 °C
	MSDS	Chinese USA	Flash Point	138.3±11.4 °C
	Symbol	GHS05, GHS06	Signal Word	Danger

Name	1-Phenylpiperazine
Synonym	More Synonyms

Density	1.0±0.1 g/cm3
Boiling Point	287.2±15.0 °C at 760 mmHg
Melting Point	18.8 °C
Molecular Formula	C₁₀H₁₄N₂
Molecular Weight	162.232
Flash Point	138.3±11.4 °C
Exact Mass	162.115692
PSA	15.27000
LogP	1.11
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.544
InChIKey	YZTJYBJCZXZGCT-UHFFFAOYSA-N
SMILES	c1ccc(N2CCNCC2)cc1
Storage condition	Store in dark!
Water Solubility	Insoluble

1-Phenylpiperazine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM2625000

CHEMICAL NAME :: Piperazine, 1-phenyl-

CAS REGISTRY NUMBER :: 92-54-6

BEILSTEIN REFERENCE NO. :: 0132157

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C10-H14-N2

MOLECULAR WEIGHT :: 162.26

WISWESSER LINE NOTATION :: T6M DNTJ DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 140 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: DNA damage

MUTATION DATA

TYPE OF TEST :: Micronucleus test

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 900 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 282,99,1992

Symbol	GHS05, GHS06
Signal Word	Danger
Hazard Statements	H301 + H311-H314
Precautionary Statements	Missing Phrase - N15.00950417-P260-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	T:Toxic;
Risk Phrases	R22;R24;R34
Safety Phrases	S26-S36/37/39-S45-S28A
RIDADR	UN 2922 8/PG 2
WGK Germany	3
RTECS	TM2625000
Packaging Group	II
Hazard Class	6.1
HS Code	29335995

Precursor 9
CAS#:77278-63-8 tert-butyl 4-ph... CAS#:4004-95-9 1-phenylpiperaz... CAS#:110-85-0 Piperazine CAS#:108-90-7 Chlorobenzene
CAS#:21057-43-2 1-allyl-4-pheny... CAS#:108-86-1 Bromobenzene CAS#:821-48-7 Bis(2-Chloroeth... CAS#:334-22-5 3-BROMO-6,7-DIH...
CAS#:591-50-4 Iodobenzene
DownStream 10
CAS#:105746-14-3 1-pentyl-4-phen... CAS#:105746-13-2 1-Phenyl-4-prop... CAS#:111277-67-9 methyl 4-phenyl... CAS#:10599-17-4 1-(3-chloroprop...
CAS#:3074-46-2 1-benzyl-4-phen... CAS#:352437-09-3 1-Boc-4-(4-Brom... CAS#:3074-43-9 1-Methyl-4-phen... CAS#:14258-45-8 1-(Diphenylmeth...
CAS#:14961-37-6 1-naphthalen-1-... CAS#:180698-19-5 1-(4-biphenylyl...

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabilizer 4-[3-(methylsulfonyl)phenyl]-1-propylpiperidine (huntexil, pridopidine, ACR16).

J. Med. Chem. 53(6) , 2510-20, (2010)

Modification of the partial dopamine type 2 receptor (D(2)) agonist 3-(1-benzylpiperidin-4-yl)phenol (9a) generated a series of novel functional D(2) antagonists with fast-off kinetic properties. A re...

Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.

J. Med. Chem. 52(15) , 4923-35, (2009)

Assembling phenylpiperazines with 7a-azaindole via different spacer elements, we developed subtype selective dopamine receptor ligands of types 1a,c, 2a, and 3a preferentially interacting with D4, D2,...

Analysis of phenylpiperazine-like stimulants in human hair as trimethylsilyl derivatives by gas chromatography-mass spectrometry.

J. Chromatogr. A. 1217(40) , 6274-80, (2010)

A simple and sensitive procedure, using p-tolylpiperazine (pTP) as internal standard (IS), has been developed and validated for the qualitative and quantitative analysis of 1-(3-trifuoromethylphenyl)p...

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 1-Phenylpiperazine
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 1-Phenylpiperazine
Price: ￥218.0/100g ￥78.0/25g ￥778.0/500g
Purity: 97.0%
Delivery: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-Phenylpiperazine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU-CHEM 92-54-6 1-Phenylpiperazine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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1-Phenylpiperazine

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