INT
INT structure
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Common Name | INT | ||
|---|---|---|---|---|
| CAS Number | 146-68-9 | Molecular Weight | 505.696 | |
| Density | N/A | Boiling Point | 567.5ºC at 760 mmHg | |
| Molecular Formula | C19H13ClIN5O2 | Melting Point | 240 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 297ºC | |
| Symbol |
GHS08 |
Signal Word | Warning | |
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MAPK15 mediates BCR-ABL1-induced autophagy and regulates oncogene-dependent cell proliferation and tumor formation.
Autophagy 11 , 1790-802, (2015) A reciprocal translocation of the ABL1 gene to the BCR gene results in the expression of the oncogenic BCR-ABL1 fusion protein, which characterizes human chronic myeloid leukemia (CML), a myeloproliferative disorder considered invariably fatal until the intro... |
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Investigating the potential of under-utilised plants from the Asteraceae family as a source of natural antimicrobial and antioxidant extracts.
Food Chem. 161 , 79-86, (2014) Antimicrobial properties of ethanol and water extracts from eight Asteraceae species were investigated against three Gram positive (Staphylococcus aureus, MRSA and Bacillus cereus) and two Gram negative (Escherichia coli and Salmonella typhimurium) bacterial ... |
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Neuraminidase inhibitory activities of quaternary isoquinoline alkaloids from Corydalis turtschaninovii rhizome.
Bioorg. Med. Chem. 22(21) , 6047-52, (2014) Clostridium perfringens is a Gram-positive spore-forming bacterium that causes food poisoning. The neuraminidase (NA) protein of C. perfringens plays a pivotal role in bacterial proliferation and is considered a novel antibacterial drug target. Based on scree... |
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Anti-Plasmodium activity of tetrazolium salts.
Bioorg. Med. Chem. 16 , 1927-47, (2008) We have previously reported that sulfated cyclodextrins inhibit the invasion of Plasmodium merozoites by interacting with receptors present on the surface of erythrocytes. The observation that tetrazolium salts formed stable complexes with the inhibitory sulf... |
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CXC chemokine ligand 12 protects pancreatic β-cells from necrosis through Akt kinase-mediated modulation of poly(ADP-ribose) polymerase-1 activity.
PLoS ONE 9(7) , e101172, (2014) The diabetes prevention paradigm envisages the application of strategies that support the maintenance of appropriate β-cell numbers. Herein we show that overexpression of CXC chemokine ligand12 (CXCL12) considerably improves the viability of isolated rat Lang... |
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IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel.
Nat. Commun. 6 , 8746, (2015) Metastatic tumour recurrence due to failed treatments remains a major challenge of breast cancer clinical management. Here we report that interleukin-1 receptor-associated kinase 1 (IRAK1) is overexpressed in a subset of breast cancers, in particular triple-n... |
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Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A.
Nat. Commun. 6 , 8048, (2015) Autophagy is a cellular catabolic process critical for cell viability and homoeostasis. Inhibition of mammalian target of rapamycin (mTOR) complex-1 (mTORC1) activates autophagy. A puzzling observation is that amino acid starvation triggers more rapid autopha... |
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IFITM1 promotes the metastasis of human colorectal cancer via CAV-1.
Cancer Lett. 368 , 135-43, (2015) Interferon-induced transmembrane protein 1 (IFITM1) is one of the interferon-induced transmembrane protein family members. In this study, we reported that the elevated IFITM1 expression in human colorectal cancer (CRC) significantly correlated with CRC lymph ... |
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Estimation of viable biomass in aerobic biodegradation processes of organic fraction of municipal solid waste (MSW).
J. Biotechnol. 101(2) , 165-72, (2003) 2-(p-Iodophenyl)-3-(p-nitrophenyl)-5-phenyltetrazolium chloride (INT) dehydrogenase test and RNA assay were introduced to evaluate biomass in the processes of aerobic biodegradation of the organic fraction of municipal solid waste (MSW) in bioreactors. It was... |
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Rapid direct methods for enumeration of specific, active bacteria in water and biofilms.
Symp. Ser. Soc. Appl. Microbiol. 85(28) , 193S-200S, (1999) Conventional methods for detecting indicator and pathogenic bacteria in water may underestimate the actual population due to sublethal environmental injury, inability of the target bacteria to take up nutrients and other physiological factors which reduce bac... |