Cancer Letters 2015-11-01

IFITM1 promotes the metastasis of human colorectal cancer via CAV-1.

Fang Yu, Dan Xie, Samuel S Ng, Ching Tung Lum, Mu-Yan Cai, William K Cheung, Hsiang-Fu Kung, Guimiao Lin, Xiaomei Wang, Marie C Lin

Index: Cancer Lett. 368 , 135-43, (2015)

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Abstract

Interferon-induced transmembrane protein 1 (IFITM1) is one of the interferon-induced transmembrane protein family members. In this study, we reported that the elevated IFITM1 expression in human colorectal cancer (CRC) significantly correlated with CRC lymph node and distance metastasis as well as a more advanced clinical stage. Importantly, elevated IFITM1 expression is an independent prognostic factor for poor survival. To investigate the molecular mechanisms, we showed that over-expression of IFITM1 in CRC cells promoted, whereas knockdown of IFITM1 expression inhibited, cell migration/invasion and tumorigenicity in vitro. Furthermore, we identified Caveolin-1 (CAV1) as a downstream target of IFITM1-induced cell invasion, as knockdown of CAV1 abrogated siIFITM1 mediated inhibition of cell invasion in CRC cells. In addition, in a CRC cohort of 229 patients, the expression of IFITM1 inversely correlated with the expression of CAV1. These results suggested that IFITM1 promotes the aggressiveness of CRC cells, and it is a potential prognostic marker and therapeutic target for CRC. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.