1-Phenylimidazole
1-Phenylimidazole structure
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Common Name | 1-Phenylimidazole | ||
|---|---|---|---|---|
| CAS Number | 7164-98-9 | Molecular Weight | 144.173 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 276.0±9.0 °C at 760 mmHg | |
| Molecular Formula | C9H8N2 | Melting Point | 13 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 120.7±18.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Influence of inhibition of the metabolic activation on the mutagenicity of some nitrosamines, triazenes, hydrazines and seniciphylline in Drosophila melanogaster.
Mutat. Res. 202(1) , 251-67, (1988) It is determined to what extent certain inhibitors of the xenobiotic metabolizing enzyme systems have an influence on the mutagenicity of various pro-mutagens in Drosophila. 1-Phenylimidazole (PhI) is used as an inhibitor of the cytochrome P-450 (P-450) media... |
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Calmodulin-dependent nitric-oxide synthase. Mechanism of inhibition by imidazole and phenylimidazoles.
J. Biol. Chem. 268(13) , 9425-9, (1993) Calmodulin-dependent nitric-oxide synthase from bovine brain and GH3 pituitary cells is inhibited by imidazole, 1-phenylimidazole, 2-phenylimidazole, and 4-phenylimidazole, with half-maximal inhibition occurring at 200, 25, 160, and 600 microM concentrations ... |
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Three-dimensional pharmacophore hypotheses for the locust neuronal octopamine receptor (OAR3). Part 2: agonists.
Bioorg. Med. Chem. 7(7) , 1437-43, (1999) Three-dimensional pharmacophore hypotheses were built from a set of 43 agonists against octopamine receptor class 3 (OAR3) in locust nervous tissue. Among the 10 chemical-featured models generated by program Catalyst/Hypo, a hypothesis including hydrogen-bond... |
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Acrolein genotoxicity in Drosophila melanogaster. III. Effects of metabolism modification.
Mutat. Res. 321(3) , 119-26, (1994) In order to investigate the role of metabolism in acrolein genotoxicity in D. melanogaster, the action of several metabolism modifiers, namely phenobarbital, an inducer of xenobiotic metabolism, phenylimidazole and iproniazid, inhibitors of oxidative activiti... |
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Chloroform-induced cytolethality in freshly isolated male B6C3F1 mouse and F-344 rat hepatocytes.
Toxicol. Appl. Pharmacol. 149(2) , 217-25, (1998) Chloroform is carcinogenic in rodents but is not mutagenic or DNA reactive. Chloroform-induced hepatocarcinogenesis in rodents is believed to be secondary to events associated with cytotoxicity and cell proliferation. Understanding the mechanisms of chlorofor... |
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Active-site structure analysis of recombinant human inducible nitric oxide synthase using imidazole.
Biochemistry 35(29) , 9567-75, (1996) Nitric oxide synthase catalyzes the pyridine nucleotide-dependent oxidation of L-arginine to nitric oxide and L-citrulline. It is a specialized cytochrome P450 monooxygenase that is sensitive to inhibition by imidazole. Steady-state kinetic studies on recombi... |
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Synthesis and identification of the quaternary ammonium-linked glucuronide of 1-phenylimidazole in human liver microsomes and investigation of the human UDP-glucuronosyltransferases involved.
Drug Metab. Dispos. 28(9) , 1009-13, (2000) 1-Phenylimidazole was investigated as a potential model substrate with respect to formation of a quaternary ammonium-linked glucuronide (N(+)-glucuronide) at an aromatic type tertiary amine. A reference sample of the potential N(+)-glucuronide metabolite of 1... |
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Effects of Asp-369 and Arg-372 mutations on heme environment and function in human endothelial nitric-oxide synthase.
J. Biol. Chem. 273(51) , 34164-70, (1998) Eight polar amino acid residues in the putative substrate-binding region from Thr-360 to Val-379 in human endothelial nitric-oxide synthase (eNOS) (Thr-360, Arg-365, Cys-368, Asp-369, Arg-372, Tyr-373, Glu-377, and Asp-378) were individually mutated. Only two... |
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Inhibition of cytochrome P-450c-mediated benzo[a]pyrene hydroxylase and ethoxyresorufin O-deethylase by dihydrosafrole.
Xenobiotica 17(7) , 793-805, (1987) 1. Inhibitory activity of dihydrosafrole towards benzo[a]pyrene (BP) hydroxylase activity in hepatic microsomes from beta-naphthoflavone (BNF)-induced rats, and in reconstituted systems containing cytochrome P-450c, increased dramatically on preincubation of ... |
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Interplanar torsion in the S1<--S0 electronic spectrum of jet cooled 1-phenylimidazole.
J. Chem. Phys. 121(24) , 12421-7, (2004) The S(1)<--S(0) transition of 1-phenylimidazole (1PI) has been studied in a supersonic jet expansion by resonant two-photon ionization. The origin band at 36 075 cm(-1) is accompanied by a low frequency progression associated with torsion about the bond conne... |