20(S)-原人参三醇

更新时间：2024-01-02 20:31:38

20(S)-原人参三醇结构式	常用名	20(S)-原人参三醇	英文名	(20S)-Protopanaxatriol
	CAS号	34080-08-5	分子量	476.73
	密度	1.1±0.1 g/cm3	沸点	588.8±50.0 °C at 760 mmHg
	分子式	C₃₀H₅₂O₄	熔点	N/A
	MSDS	中文版美版	闪点	242.9±24.7 °C

20(S)-原人参三醇用途

(20S)-Protopanaxatriol 是人参皂苷的代谢物,通过 glucocorticoid receptor 和 oestrogen receptor 起作用,同时为 LXRα 的抑制剂。

中文名	原人参三醇
英文名	protopanaxatriol
中文别名	(S型)原人参三醇
英文别名	更多

描述	(20S)-Protopanaxatriol 是人参皂苷的代谢物,通过 glucocorticoid receptor 和 oestrogen receptor 起作用,同时为 LXRα 的抑制剂。
相关类别	信号通路 >> 其他 >> 雌激素受体/ERR 信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体信号通路 >> 代谢酶/蛋白酶 >> LXR 研究领域 >> 心血管疾病天然产物 >> 类固醇
靶点	Glucocorticoid receptor, Oestrogen receptor[1], LXRα[2]
体外研究	(20S)-Protopanaxatriol通过人脐静脉内皮细胞(HUVEC)中的糖皮质激素受体(GR)和雌激素受体(ER)起作用。 (20S)-Protopanaxatriol(g-PPT)在HUVEC中增加[Ca2 +] i,EC50为482nM。 (20S)-Protopanaxatriol(1μM)通过ERβ提高NO产生[1]。 (20S)-Protopanaxatriol(PPT)抑制Gal4-LXRαLBD的自主反式激活,这是T0901317依赖的SREBP-1c及其启动子的转录。 (20S)-Protopanaxatriol(10μg/ mL)阻断RNA聚合酶II向SREBP-1c的LXRE区域的募集。 (20S)-Protopanaxatriol还抑制与脂肪生成相关的LXRα靶基因的T0901317依赖性转录,并减少T0901317诱导的原代肝细胞中的细胞甘油三酯(TG)积累,但不改变ABCA1的转录,也是LXRα靶基因的转录[2] 。
参考文献	[1]. Leung KW, et al. Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells. Br J Pharmacol. 2009 Feb;156(4):626-37. [2]. Oh GS, et al. 20(S)-protopanaxatriol inhibits liver X receptor α-mediated expression of lipogenic genes in hepatocytes. J Pharmacol Sci. 2015 Jun;128(2):71-7.

密度	1.1±0.1 g/cm3
沸点	588.8±50.0 °C at 760 mmHg
分子式	C₃₀H₅₂O₄
分子量	476.73
闪点	242.9±24.7 °C
PSA	80.92000
LogP	5.41
蒸汽压	0.0±3.7 mmHg at 25°C
折射率	1.541
储存条件	-20°C

危险品运输编码	NONH for all modes of transport

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PROTOPANAXTRIOL

20(S)-APPT,g-PPT

Gonane-3,6,12-triol, 17-[(1S)-1-hydroxy-1,5-dimethyl-4-hexen-1-yl]-4,4,10,14-tetramethyl-, (3β,6α,12β,14β,17β)-

(3β,6α,12β,14β)-4,4,14-Trimethyl-18-norcholest-24-ene-3,6,12,20-tetrol

20S-Protopanaxatriol

Protopanaxatriol, 20S-

(20S)-Protopanaxatriol