(20S)-Protopanaxatriol

Modify Date: 2024-01-02 20:31:38

(20S)-Protopanaxatriol structure	Common Name	(20S)-Protopanaxatriol
	CAS Number	34080-08-5	Molecular Weight	476.73
	Density	1.1±0.1 g/cm3	Boiling Point	588.8±50.0 °C at 760 mmHg
	Molecular Formula	C₃₀H₅₂O₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	242.9±24.7 °C

Use of (20S)-Protopanaxatriol

(20S)-Protopanaxatriol is a metabolite of ginsenoside, works through the glucocorticoid receptor (GR) and oestrogen receptor (ER), and is also a LXRα inhibitor.

Name	protopanaxatriol
Synonym	More Synonyms

Description	(20S)-Protopanaxatriol is a metabolite of ginsenoside, works through the glucocorticoid receptor (GR) and oestrogen receptor (ER), and is also a LXRα inhibitor.
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Signaling Pathways >> Metabolic Enzyme/Protease >> LXR Research Areas >> Cardiovascular Disease Natural Products >> Steroids
Target	Glucocorticoid receptor, Oestrogen receptor[1], LXRα[2]
In Vitro	(20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and oestrogen receptor (ER) in human umbilical vein endothelial cells (HUVECs). (20S)-Protopanaxatriol (g-PPT) increases [Ca2+]i with an EC50 of 482 nM in HUVECs. (20S)-Protopanaxatriol (1 µM) elevates NO production via ERβ[1]. (20S)-Protopanaxatriol (PPT) inhibits the autonomous transactivation of Gal4-LXRα LBD, the T0901317-dependent transcription of SREBP-1c and its promoter. (20S)-Protopanaxatriol (10 μg/mL) blocks the recruitment of RNA polymerase II to the LXRE region of SREBP-1c. (20S)-Protopanaxatriol also inhibits T0901317-dependent transcription of LXRα target genes related to lipogenesis, and reduces T0901317-induced cellular triglyceride (TG) accumulation in primary hepatocytes, but does not alter transcription of ABCA1, also an LXRα target gene[2].
References	[1]. Leung KW, et al. Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells. Br J Pharmacol. 2009 Feb;156(4):626-37. [2]. Oh GS, et al. 20(S)-protopanaxatriol inhibits liver X receptor α-mediated expression of lipogenic genes in hepatocytes. J Pharmacol Sci. 2015 Jun;128(2):71-7.

Density	1.1±0.1 g/cm3
Boiling Point	588.8±50.0 °C at 760 mmHg
Molecular Formula	C₃₀H₅₂O₄
Molecular Weight	476.73
Flash Point	242.9±24.7 °C
PSA	80.92000
LogP	5.41
Vapour Pressure	0.0±3.7 mmHg at 25°C
Index of Refraction	1.541
Storage condition	-20°C

RIDADR	NONH for all modes of transport

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PROTOPANAXTRIOL

20(S)-APPT,g-PPT

Gonane-3,6,12-triol, 17-[(1S)-1-hydroxy-1,5-dimethyl-4-hexen-1-yl]-4,4,10,14-tetramethyl-, (3β,6α,12β,14β,17β)-

(3β,6α,12β,14β)-4,4,14-Trimethyl-18-norcholest-24-ene-3,6,12,20-tetrol

20S-Protopanaxatriol

Protopanaxatriol, 20S-

(20S)-Protopanaxatriol