BioBioPha
China
Product Name: (20S)-Protopanaxatriol
Price: ￥Inquiry/50mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: (20S)-Protopanaxatriol
Price: ￥298.0/20mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: PROTOPANAXTRIOL
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: (20S)-Protopanaxatriol
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

34080-08-5

34080-08-5 structure

34080-08-5 structure

Name: (20S)-Protopanaxatriol
Chemical Name: protopanaxatriol
CAS Number: 34080-08-5
Molecular Formula: C₃₀H₅₂O₄
Molecular Weight: 476.73
Catalog: Natural product Moss
Create Date: 2018-04-08 08:00:00
Modify Date: 2024-01-02 20:31:38
(20S)-Protopanaxatriol is a metabolite of ginsenoside, works through the glucocorticoid receptor (GR) and oestrogen receptor (ER), and is also a LXRα inhibitor.

Name	protopanaxatriol
Synonyms	PROTOPANAXTRIOL 20(S)-APPT,g-PPT Gonane-3,6,12-triol, 17-[(1S)-1-hydroxy-1,5-dimethyl-4-hexen-1-yl]-4,4,10,14-tetramethyl-, (3β,6α,12β,14β,17β)- (3β,6α,12β,14β)-4,4,14-Trimethyl-18-norcholest-24-ene-3,6,12,20-tetrol 20S-Protopanaxatriol Protopanaxatriol, 20S- (20S)-Protopanaxatriol

Description	(20S)-Protopanaxatriol is a metabolite of ginsenoside, works through the glucocorticoid receptor (GR) and oestrogen receptor (ER), and is also a LXRα inhibitor.
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Signaling Pathways >> Metabolic Enzyme/Protease >> LXR Research Areas >> Cardiovascular Disease Natural Products >> Steroids
Target	Glucocorticoid receptor, Oestrogen receptor[1], LXRα[2]
In Vitro	(20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and oestrogen receptor (ER) in human umbilical vein endothelial cells (HUVECs). (20S)-Protopanaxatriol (g-PPT) increases [Ca2+]i with an EC50 of 482 nM in HUVECs. (20S)-Protopanaxatriol (1 µM) elevates NO production via ERβ[1]. (20S)-Protopanaxatriol (PPT) inhibits the autonomous transactivation of Gal4-LXRα LBD, the T0901317-dependent transcription of SREBP-1c and its promoter. (20S)-Protopanaxatriol (10 μg/mL) blocks the recruitment of RNA polymerase II to the LXRE region of SREBP-1c. (20S)-Protopanaxatriol also inhibits T0901317-dependent transcription of LXRα target genes related to lipogenesis, and reduces T0901317-induced cellular triglyceride (TG) accumulation in primary hepatocytes, but does not alter transcription of ABCA1, also an LXRα target gene[2].
References	[1]. Leung KW, et al. Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells. Br J Pharmacol. 2009 Feb;156(4):626-37. [2]. Oh GS, et al. 20(S)-protopanaxatriol inhibits liver X receptor α-mediated expression of lipogenic genes in hepatocytes. J Pharmacol Sci. 2015 Jun;128(2):71-7.

Density	1.1±0.1 g/cm3
Boiling Point	588.8±50.0 °C at 760 mmHg
Molecular Formula	C₃₀H₅₂O₄
Molecular Weight	476.73
Flash Point	242.9±24.7 °C
PSA	80.92000
LogP	5.41
Vapour Pressure	0.0±3.7 mmHg at 25°C
Index of Refraction	1.541
Storage condition	-20°C

RIDADR	NONH for all modes of transport