1808-12-4

• 常用中文名：2-[(4-溴苯基)苯基甲氧基]-N,N-二甲基-乙胺盐酸盐
• 常用英文名：Bromodiphenhydramine hydrochloride
• CAS号：1808-12-4
• 分子式：C₁₇H₂₁BrClNO
• 分子量：370.71200
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2018-06-18 20:39:25
• 更新时间：2024-01-19 19:53:52
• 溴二苯肼盐酸盐是一种具有抗菌性能的强效抗组胺药。溴二苯肼盐酸盐抑制大量革兰氏阴性和革兰氏阳性细菌。溴二苯肼盐酸盐可用于皮肤过敏研究[1][2][3]。

名称

• 中文名: 盐酸苯海拉明杂质C
• 英文名: bromazine hydrochloride
• 中文别名: 乘晕宁杂质H
• 英文别名: [2-(4-Brom-benzhydryloxy)-aethyl]-dimethyl-amin,Hydrochlorid; Bromdiphenhydramine hydrochloride; Bromdiphenylhydramine hydrochloride; Bromodiphenhydramine hydrochloride; 2-[(4-bromophenyl)phenylmethoxy]ethyl(dimethyl)ammonium chloride; phenyl(p-bromophenyl)(dimethylaminoethoxy)methane hydrochloride; 2-[(4-bromophenyl)-phenylmethoxy]ethyl-dimethylazanium,chloride; Bromazine hydrochloride; 2-[(4-bromophenyl)phenylmethoxy]-N,N-dimethyl-ethanamine,hydrochloride; [2-(4-bromo-benzhydryloxy)-ethyl]-dimethyl-amine,hydrochloride; EINECS 217-310-9; Bromodiphenhydramine HCl

物化性质

• 沸点: 397.3ºC at 760 mmHg
• 分子式: C₁₇H₂₁BrClNO
• 分子量: 370.71200
• 闪点: 194.1ºC
• 精确质量: 369.05000
• PSA: 12.47000
• LogP: 4.91870
• 外观性状: 固体
• 蒸汽压: 1.61E-06mmHg at 25°C
• 储存条件: 库房通风低温干燥,与食品原料类分开存放

生物活性

• 描述: 溴二苯肼盐酸盐是一种具有抗菌性能的强效抗组胺药。溴二苯肼盐酸盐抑制大量革兰氏阴性和革兰氏阳性细菌。溴二苯肼盐酸盐可用于皮肤过敏研究[1][2][3]。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 感染
  研究领域 >> 炎症/免疫
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
  信号通路 >> 抗感染 >> 细菌
• 体内研究: 溴二苯肼盐酸盐(1.5和3μg/g,单次)保护小鼠免受鼠伤寒沙门氏菌毒株的攻击,与未受保护的对照组相比,还显著减少了受保护动物肝脏、脾脏和血液中该生物体的增殖[2]。
• 参考文献:

  [1]. MOLINA EB. [A new antihistaminic, bromodiphenhydramine hydrochloride, in the control of cutaneous allergies]. Sem Med. 1960 Jul 11;117:151-2. Spanish.

  [2]. Dastidar SG, et al. Antibacterial activity of ambodryl and benadryl. J Appl Bacteriol. 1976 Oct;41(2):209-14.

  [3]. Ray S, et al. Studies on synergism between penicillins and ambodryl (bromodiphenhydramine HCl), an antihistamine with antimicrobial property. Indian J Exp Biol. 1990 Mar;28(3):253-8.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KQ8420000 CHEMICAL NAME : Ethylamine, 2-((p-bromo-alpha-phenylbenzyl)oxy)-N,N-dimethyl-, hydrochloride CAS REGISTRY NUMBER : 1808-12-4 LAST UPDATED : 199504 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C17-H20-Br-N-O.Cl-H MOLECULAR WEIGHT : 370.75 WISWESSER LINE NOTATION : ER DYR&O2N1&1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 602 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 55 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 366 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 105 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 112,318,1954 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 63 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 21 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81737 No. of Facilities: 805 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 805 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81737 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 82 (estimated) No. of Female Employees: 14 (estimated)

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 警示性声明: P301 + P312 + P330
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2922199090

合成路线

118-23-0 ~% 1808-12-4

文献：Medicinal Chemistry Research, , vol. 21, # 11 p. 3532 - 3540

29334-16-5 ~% 1808-12-4

文献：Medicinal Chemistry Research, , vol. 21, # 11 p. 3532 - 3540

18066-89-2 ~% 1808-12-4

文献：Medicinal Chemistry Research, , vol. 21, # 11 p. 3532 - 3540

上下游产品

上游产品  3
118-23-0 29334-16-5 18066-89-2
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海关

海关编码	2922199090
中文概述	2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%