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1808-12-4

1808-12-4 structure
1808-12-4 structure
  • Name: Bromodiphenhydramine hydrochloride
  • Chemical Name: bromazine hydrochloride
  • CAS Number: 1808-12-4
  • Molecular Formula: C17H21BrClNO
  • Molecular Weight: 370.71200
  • Catalog: Signaling Pathways Anti-infection Bacterial
  • Create Date: 2018-06-18 20:39:25
  • Modify Date: 2025-08-24 14:03:57
  • Bromodiphenhydramine hydrochloride is a potent antihistamine with antimicrobial property. Bromodiphenhydramine hydrochloride inhibits a large number of Gram negative and Gram positive bacteria. Bromodiphenhydramine hydrochloride can be used for cutaneous allergies research[1][2][3].
Name bromazine hydrochloride
Synonyms [2-(4-Brom-benzhydryloxy)-aethyl]-dimethyl-amin,Hydrochlorid
Bromdiphenhydramine hydrochloride
Bromdiphenylhydramine hydrochloride
Bromodiphenhydramine hydrochloride
2-[(4-bromophenyl)phenylmethoxy]ethyl(dimethyl)ammonium chloride
phenyl(p-bromophenyl)(dimethylaminoethoxy)methane hydrochloride
2-[(4-bromophenyl)-phenylmethoxy]ethyl-dimethylazanium,chloride
Bromazine hydrochloride
2-[(4-bromophenyl)phenylmethoxy]-N,N-dimethyl-ethanamine,hydrochloride
[2-(4-bromo-benzhydryloxy)-ethyl]-dimethyl-amine,hydrochloride
EINECS 217-310-9
Bromodiphenhydramine HCl
Description Bromodiphenhydramine hydrochloride is a potent antihistamine with antimicrobial property. Bromodiphenhydramine hydrochloride inhibits a large number of Gram negative and Gram positive bacteria. Bromodiphenhydramine hydrochloride can be used for cutaneous allergies research[1][2][3].
Related Catalog
In Vivo Bromodiphenhydramine hydrochloride (1.5 and 3 μg/g, single) protects mice against a challenge with a virulent strain of Salmonella typhimurium, and also significantly reduces the multiplication of this organism in the liver, spleen and blood of the protected animals in comparison with the unprotected controls[2].
References

[1]. MOLINA EB. [A new antihistaminic, bromodiphenhydramine hydrochloride, in the control of cutaneous allergies]. Sem Med. 1960 Jul 11;117:151-2. Spanish.

[2]. Dastidar SG, et al. Antibacterial activity of ambodryl and benadryl. J Appl Bacteriol. 1976 Oct;41(2):209-14.

[3]. Ray S, et al. Studies on synergism between penicillins and ambodryl (bromodiphenhydramine HCl), an antihistamine with antimicrobial property. Indian J Exp Biol. 1990 Mar;28(3):253-8. 
Boiling Point 397.3ºC at 760 mmHg
Molecular Formula C17H21BrClNO
Molecular Weight 370.71200
Flash Point 194.1ºC
Exact Mass 369.05000
PSA 12.47000
LogP 4.91870
Vapour Pressure 1.61E-06mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KQ8420000
CHEMICAL NAME :
Ethylamine, 2-((p-bromo-alpha-phenylbenzyl)oxy)-N,N-dimethyl-, hydrochloride
CAS REGISTRY NUMBER :
1808-12-4
LAST UPDATED :
199504
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C17-H20-Br-N-O.Cl-H
MOLECULAR WEIGHT :
370.75
WISWESSER LINE NOTATION :
ER DYR&O2N1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
602 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
55 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
366 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
105 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 112,318,1954
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
63 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
21 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81737 No. of Facilities: 805 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 805 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81737 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 82 (estimated) No. of Female Employees: 14 (estimated)
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
RIDADR NONH for all modes of transport
HS Code 2922199090
Precursor  3

DownStream  0

HS Code 2922199090
Summary 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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