102115-79-7

• 常用中文名：伪原薯蓣皂苷
• 常用英文名：Pseudoprotodioscin
• CAS号：102115-79-7
• 分子式：C₅₁H₈₂O₂₁
• 分子量：1031.184
• 相关类别： 生物化工 中草药成分
• 发布时间：2018-02-16 08:00:00
• 更新时间：2026-07-08 17:38:51
• 伪原薯蓣皂苷白色结晶，溶于甲醇、水，难溶于丙酮、乙酸乙酯，来源于黄山药，穿山龙，盾叶薯蓣。具有抗缺氧的作用。

名称

• 中文名: 伪原薯蓣皂甙
• 英文名: protogracellin
• 中文别名: 伪薯蓣皂苷; 伪原薯蓣皂苷(对照品); 伪原薯蓣皂苷Pseudoprotodioscin; (2S,2'S,3R,3'R,4R,4'R,5R,5'R,6S,6'S)-6,6'-(((2R,3S,4S,5R,6R)-4-羟基-2-(羟甲基)-6-(((6,6BS,8AS,8BS,11AS,12AS,12BS)-6A,8A,9-三甲基-10-((R)-3-甲基-4-(((2R,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)丁基)-3,4,5,6,6A,6B,7,8,8A,8B,11A,12,12A,12B-十四氢-1H-萘并[2',1':4; 伪原薯蓣皂苷(伪薯蓣皂苷,伪原薯預皂苷); 伪原薯蓣皂苷,10 MM DMSO 溶液; 化合物:Pseudoprotodioscin; 伪原薯蓣皂苷, 来源于薯蓣; 化合物：Pseudoprotodioscin; 伪原薯預皂苷; Pseudoprotodioscin :伪原薯蓣皂苷; PSEDUOPROTODIOSCIN 伪原薯蓣皂苷; 伪原薯蓣皂苷(伪薯蓣皂苷); 抑制剂Pseudoprotodioscin; (2S,2'S,3R,3'R,4R,4'R,5R,5'R,6S,6'S)-6,6'-(((2R,3S,4S,5R,6R)-4-羟基-2-(羟甲基)-6-(((6,6bS,8aS,8bS,11aS,12aS,12bS)-6a,8a,9-三甲基-10-((R)-3-甲基-4-(((2R,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)丁基)-3,4,5,6,6a,6b,7,8,8a,8b,11a,12,12a,12b-十四氢-1H-萘并[2',1':4,5]茚并
• 英文别名: Pseudoprotodioscin, 10 mM in DMSO; β-D-Glucopyranoside, (25R)-3-[[O-6-deoxy-α-L-mannopyranosyl-(1->2)-O-[6-deoxy-α-L-mannopyranosyl-(1->4)]-β-D-glucopyranosyl]oxy]furosta-5,20(22)-dien-27-yl; (3β,25R)-26-(β-D-Glucopyranosyloxy)furosta-5,20(22)-dien-3-yl 6-deoxy-α-L-mannopyranosyl-(1->;2)-[6-deoxy-α-L-mannopyranosyl-(1->;4)]-β-D-glucopyranoside; PROTODIOSCIN,PSEUDO; (25R)-26-(β-D-Glucopyranosyloxy)furosta-5,20(22)-dien-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[6-deoxy-α-L-mannopyranosyl-(1->4)]-β-D-glucopyranoside; PROTOACELLIN //BP; PSEUDOPROTOTRIBESTIN; pseudo-Protodioscin; Pseudoprotodioscin(P); PROTODIOSCIN, PSEUDO; PROTOACELLIN; PSEUDO-PROTODIOSCIN; Pseduoprotodioscin; Protoacellin from Dioscorea opposita Thunb; (2S,2'S,3R,3'R,4R,4'R,5R,5'R,6S,6'S)-6,6'-(((2R,3S,4S,5R,6R)-4-Hydroxy-2-(hydroxymethyl)-6-(((6,6bS,8aS,8bS,11aS,12aS,12bS)-6a,8a,9-trimethyl-10-((R)-3-methyl-4-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)butyl)-3,4,5,6,6a,6b,7,8,8a,8b,11a,12,12a,12b-tetradecahydro-1H-naphtho[2',1':4,5]indeno[2,1-b]furan-4-yl)oxy)tetrahydro-2H-pyran-3,5-diyl)bis(oxy))bis(2-methyltetrahydro-2H-pyran-3,4,5-triol); (25R)-3-{[6-Deoxy-α-L-mannopyranosyl-(1->2)-[6-deoxy-α-L-mannopyranosyl-(1->4)]-β-D-glucopyranosyl]oxy}furosta-5,20(22)-dien-27-yl β-D-glucopyranoside; β-D-Glucopyranoside, (3β,25R)-26-(β-D-glucopyranosyloxy)furosta-5,20-dien-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]

物化性质

• 密度: 1.45 g/cm3
• 分子式: C₅₁H₈₂O₂₁
• 分子量: 1031.184
• 精确质量: 1030.534912
• PSA: 325.83000
• LogP: 5.31
• 折射率: 1.631

生物活性

• 描述: Pseudoprotodioscin,一种呋喃葡糖苷,抑制 SREBP1/2 和 microRNA 33a/b 水平,降低胆固醇和甘油三酯合成相关的基因表达。
• 相关类别:
  信号通路 >> 表观遗传学 >> 微RNA
  信号通路 >> 代谢酶/蛋白酶 >> 脂肪酸合成酶(FAS)
  研究领域 >> 代谢疾病
• 体外研究: 在HepG2细胞中,假原薯干蛋白增加ABCA1蛋白和mRNA水平,并促进APOA-1介导的胆固醇的流出。伪原薯蓣皂苷通过降低microRNA 33a/b水平抑制SREBP1c和SREBP2的转录。这个过程反过来导致ABCA1水平的升高。在THP-1巨噬细胞中,伪原薯蓣皂苷具有类似的作用,通过降低PCSK9水平,降低HMGCR、FAS和ACC mRNA水平,促进低密度脂蛋白受体[1]。
• 参考文献:

  [1]. Gai Y, et al. Pseudoprotodioscin inhibits SREBPs and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides. Fitoterapia. 2019 Nov;139:104393.

  [2]. Liang ZZ, et al. Oligofurostanosides from Asparagus cochinchinensis. Planta Med. 1988 Aug;54(4):344-6.

安全

• 安全声明 (欧洲): S24/25
• 海关编码: 29389090