2-甲基-4(5)硝基咪唑
2-甲基-4(5)硝基咪唑结构式
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常用名 | 2-甲基-4(5)硝基咪唑 | 英文名 | 2-Methyl-4-nitroimidazole |
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| CAS号 | 696-23-1 | 分子量 | 127.10100 | |
| 密度 | 1.426g/cm3 | 沸点 | 399.5ºC at 760 mmHg | |
| 分子式 | C4H5N3O2 | 熔点 | 251-255ºC(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 195.4ºC | |
| 符号 |
GHS08 |
信号词 | Warning |
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On the hydrolytic behavior of tinidazole, metronidazole, and ornidazole.
J. Pharm. Sci. 92(4) , 739-46, (2003) Using two UV-spectrophotometric methods, the hydrolysis of tinidazole was studied at pH 1.00-8.45 at 80 degrees C. The reaction followed apparent first-order kinetics throughout the studied range. No kinetic salt effect was detected, indicating that at least ... |
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Radicals of nitroimidazole derivatives: pH dependence of rates of formation and decay related to acid-base equilibria.
Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 51(5) , 797-809, (1987) Three analogous 5-nitroimidazoles, having radiosensitizing and cytotoxic properties, have been studied by pulse-radiolysis in N2O-saturated aqueous formate solutions. Rates of formation of the radicals ImNO2-. are found to have little pH dependence. Decay of ... |
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[Synthesis and antibacterial activity of ciprofloxacin derivatives].
Yao Xue Xue Bao 40(2) , 132-5, (2005) To study the synthesis and antibacterial activity of ciprofloxacin derivatives.Ciprofloxacin derivatives were synthesized primarily from 2-methyl-5-nitroimidazol and ciprofloxacin through nucleophilic substitution. The antibacterial activity of the synthesize... |
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[Synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol].
Yao Xue Xue Bao 38(4) , 260-3, (2003) To study the synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol.Pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol were synthesized primarily from 2-methyl-5-nitroimidazol, norf... |
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[Determination of acid-base amphoteric dissociation constant of 2-methyl-5 (4)-nitroimidazole by UV-spectrophotometry].
Hua Xi Yi Ke Da Xue Xue Bao 30(3) , 345-6, (1999) The 2-methyl-5(4)-nitromidazole(BH) is an ampholyte with acid and base. It is an intermediate of metronidazole. The amphoteric dissociation constant of BH determined by equimolar UV-spectrophotometry. The acidic dissociation constant pKa is 9.64 +/- 0.04 and ... |
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Synthesis of 3'-azolyl-2',3'-dideoxyhexose nucleosides.
Acta Chem. Scand. 52(7) , 935-41, (1998) 1,8-Diazabicyclo[5.4.0]undec-7-ene salts of 2-methyl-4(5)-nitroimidazole or benzotriazole were obtained in crystalline form. Michael-type addition of these salts to (4S,5R)-(E)-4,6-di-O-acetyl-5-hydroxy-2-hexenal gave, after acetylation of the product, an iso... |
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Evaluation of 99mTc(CO)3 complex of 2-methyl-5-nitroimidazole as an agent for targeting tumor hypoxia.
Bioorg. Med. Chem. 14(23) , 7666-70, (2006) An iminodiacetic acid (IDA) derivative of 2-methyl-5-nitroimidazole was synthesized as a carrier molecule for radiolabeling with the gamma emitting radioisotope, 99mTc, for imaging hypoxic regions of tumors. The ligand was synthesized in excellent yield and l... |
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A comparative study on vibrational, conformational and electronic structure of 1,2-dimethyl-5-nitroimidazole and 2-methyl-5-nitroimidazole.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 97 , 176-88, (2012) The FTIR and FT-Raman spectra of 1,2-dimethyl-5-nitroimidazole and 2-methyl-5-nitroimidazole have been recorded in the regions 4000-400 and 4000-100 cm(-1), respectively. The conformational analyses were performed and the energies of the different possible co... |
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The identification and assay of 2-methyl-5-nitroimidazole in pigs treated with dimetridazole.
Food Addit. Contam. 8(4) , 467-75, (1991) An unidentified metabolite of dimetridazole (DMZ), found in pig plasma, muscle and kidney, was shown by chromatography and spectroscopy to be 2-methyl-5-nitroimidazole (2-MNI), resulting from N-demethylation of DMZ. This route of degradation competes with the... |
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Radiosynthesis and evaluation of two novel 123I-labeled 2-methyl-4-nitroimidazole derivatives as potential infection imaging agents.
Nucl. Med. Biol. 32(4) , 385-94, (2005) The inflammation- and infection-seeking properties of (131)I-labeled ornidazole, a 5-nitroimidazole derivative, have recently been reported. Whole-body images in rabbits showed a more rapid uptake in inflamed areas compared to (67)Ga. In the present study, tw... |