杆菌肽 A
杆菌肽 A结构式
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常用名 | 杆菌肽 A | 英文名 | Bacitracin A1 (9CI) |
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| CAS号 | 22601-59-8 | 分子量 | 1422.69000 | |
| 密度 | 1.43 g/cm3 | 沸点 | 1755.5ºC at 760 mmHg | |
| 分子式 | C66H103N17O16S | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 1015.5ºC |
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Validation of a quantitative HPLC method for bacitracin and bacitracin zinc using EDTA as a mobile-phase modifier.
J. Pharm. Biomed. Anal. 70 , 619-23, (2012) Any product marketed in the United States and labeled bacitracin must comply with the tests, procedures, and acceptance criteria in the relevant monograph published in the US Pharmacopeia (USP). The test procedure relies on accurate recovery of Bacitracin A a... |
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Dereplicating nonribosomal peptides using an informatic search algorithm for natural products (iSNAP) discovery.
Proc. Natl. Acad. Sci. U. S. A. 109(47) , 19196-201, (2012) Nonribosomal peptides are highly sought after for their therapeutic applications. As with other natural products, dereplication of known compounds and focused discovery of new agents within this class are central concerns of modern natural product-based drug ... |
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Affinity capillary electrophoresis study of the linkage existing between proton and zinc ion binding to bacitracin A1.
Electrophoresis 24(5) , 801-7, (2003) Measurements by capillary electrophoresis (CE) of bacitracin A(1) effective mobility at different pH values permitted to estimate the five acidic dissociation constants and the Stokes radii at different protonation stages of the macrocyclic dodecapeptide. The... |
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Detection of residual bacitracin A, colistin A, and colistin B in milk and animal tissues by liquid chromatography tandem mass spectrometry.
Anal. Bioanal. Chem 385(1) , 181-8, (2006) Liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-MS/MS) was applied to the determination of residual bacitracin A, colistin A, and colistin B in milk and animal tissue samples. Prior to instrumental analysis, samples wer... |
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Total structures and antimicrobial activity of bacitracin minor components.
J. Antibiot. 48(3) , 233-42, (1995) Total structures of 13 minor components of bacitracin (BC) were proposed, and their antimicrobial activities were investigated. The components of BC including bacitracins A (BC-A) and F (BC-F) were isolated by preparative HPLC and were hydrolyzed under acidic... |
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1H NMR study on the conformation of bacitracin A in aqueous solution.
FEBS Lett. 305(2) , 105-9, (1992) The conformation of bacitracin A, a widely used cyclic dodecapeptide antibiotic in aqueous solution, has been investigated using 500 MHz 1H NMR and molecular modeling. Findings revealed that a region (residues 1-6) is folded over the cyclic ring, resulting in... |
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Capillary electrophoretic study of the binding of zinc(II) ion to bacitracin A1 in water-2,2,2-trifluoroethanol.
Electrophoresis 24(10) , 1612-9, (2003) Binding of Zn(2+) to bacitracin A(1) was studied by capillary electrophoresis in water/2,2,2-trifluoroethanol (70/30 v/v) at different apparent pH values in order to estimate the association constant of metal, the acidic dissociation constants and the Stokes ... |
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[Sporulation in Bacillus licheniformis during altered bacitracin synthesis].
Antibiotiki 28(7) , 494-7, (1983) Sporulation in different strains of Bacillus licheniformis, 10716 and 1001 in connection with changes in synthesis of bacitracin was studied. It was shown that the sporulation efficiency did not depend on the synthesis of the antibiotic: in some strains with ... |
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X-Ray structure of the antibiotic bacitracin A.
FEBS Lett. 285(1) , 115-9, (1991) Bacitracins are a group of widely used peptide antibiotics. There has been interest in determining the three-dimensional structure of the bacitracins. However, solution studies indicate significant flexibility in their structure and to date native bacitracins... |
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Study of correlations between fine structure of bonded layer and affinity properties of silicas with attached cyclic oligopeptides.
J. Chromatogr. A. 777(2) , 249-59, (1997) The cyclic oligopeptides bacitracin A and gramicidin-S were immobilized on epoxy-, tosyloxy- and halogenoaklyl-activated silicas. The sorbents obtained were tested for affinity binding of proteinases. The effects of spacer length, ligand loading and the chara... |