毒黄素
毒黄素结构式
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常用名 | 毒黄素 | 英文名 | Toxoflavin |
|---|---|---|---|---|
| CAS号 | 84-82-2 | 分子量 | 193.16300 | |
| 密度 | 1.65g/cm3 | 沸点 | 276.7ºC at 760 mmHg | |
| 分子式 | C7H7N5O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 121.1ºC | |
| 符号 |
GHS06 |
信号词 | Danger |
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Investigations into the Biosynthesis, Regulation, and Self-Resistance of Toxoflavin in Pseudomonas protegens Pf-5.
ChemBioChem. 16 , 1782-90, (2015) Pseudomonas spp. are prolific producers of natural products from many structural classes. Here we show that the soil bacterium Pseudomonas protegens Pf-5 is capable of producing trace levels of the triazine natural product toxoflavin (1) under microaerobic co... |
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The quorum sensing-dependent gene katG of Burkholderia glumae is important for protection from visible light.
J. Bacteriol. 191(13) , 4152-7, (2009) Quorum sensing (QS) plays important roles in the pathogenicity of Burkholderia glumae, the causative agent of bacterial rice grain rot. We determined how QS is involved in catalase expression in B. glumae. The QS-defective mutant of B. glumae exhibited less c... |
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Identification of the product of toxoflavin lyase: degradation via a Baeyer-Villiger oxidation.
J. Am. Chem. Soc. 134(11) , 5326-30, (2012) Toxoflavin (an azapteridine) is degraded to a single product by toxoflavin lyase (TflA) in a reaction dependent on reductant, Mn(II), and oxygen. The isolated product was fully characterized by NMR and MS and was identified as a triazine in which the pyrimidi... |
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[The stacking interaction of antibiotics of the pyrimido[5,4-e]-1,2,4-triazine series with purines].
Izv. Akad. Nauk Ser. Biol. (1) , 145-7, (1994) The changes in the PMR spectra of purine bases added to aqueous solutions (D2O) of antibiotics of the pyrimido[5,4-e]-1,2,4-triazine type, reumycin and xanthotricin as well as the changes in the PMR indicate formation of heteroassociates with batch structure ... |
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Structural and functional analysis of phytotoxin toxoflavin-degrading enzyme.
PLoS ONE 6(7) , e22443, (2011) Pathogenic bacteria synthesize and secrete toxic low molecular weight compounds as virulence factors. These microbial toxins play essential roles in the pathogenicity of bacteria in various hosts, and are emerging as targets for antivirulence strategies. Toxo... |
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Simultaneous determination of toxic metabolites by linear combination derivative spectrophotometry.
Analyst 116(9) , 919-22, (1991) A linear combination derivative spectrophotometric method is described. The method overcomes the problem of overlapping in derivative spectrophotometry and allows the maximum use of quantitative information. In addition, the method can be used to increase the... |
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Toxoflavin lyase requires a novel 1-His-2-carboxylate facial triad.
Biochemistry 50(6) , 1091-100, (2011) High-resolution crystal structures are reported for apo, holo, and substrate-bound forms of a toxoflavin-degrading metalloenzyme (TflA). In addition, the degradation reaction is shown to be dependent on oxygen, Mn(II), and dithiothreitol in vitro. Despite its... |
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Biochemical evidence for ToxR and ToxJ binding to the tox operons of Burkholderia glumae and mutational analysis of ToxR.
J. Bacteriol. 191(15) , 4870-8, (2009) Burkholderia glumae produces toxoflavin, a phytotoxin with a broad host range, which is a key virulence factor in bacterial rice grain rot. Based on genetic analysis, we previously reported that ToxR, a LysR-type regulator, activates both the toxABCDE (toxofl... |
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Toxoflavin lyase enzyme as a marker for selecting potato plant transformants.
Biosci. Biotechnol. Biochem. 76(12) , 2354-6, (2012) This study established a new system for potato transformation using toxoflavin as selection agent and toxoflavin lyase (tflA) as selectable marker gene. Potato plants expressing tflA was successfully transformed on toxoflavin medium with 27% efficiency, simil... |
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AiiA-mediated quorum quenching does not affect virulence or toxoflavin expression in Burkholderia glumae SL2376.
Lett. Appl. Microbiol. 51(6) , 619-24, (2010) The primary objective of this study was to determine the effects of quorum quenching in the pathogenicity and toxoflavin production of Burkholderia glumae causing bacterial rice grain rot.An acyl-homoserine lactonase (aiiA) gene from Bacillus sp. was expresse... |