Toxoflavin

Modify Date: 2024-01-06 15:35:11

Toxoflavin structure	Common Name	Toxoflavin
	CAS Number	84-82-2	Molecular Weight	193.16300
	Density	1.65g/cm3	Boiling Point	276.7ºC at 760 mmHg
	Molecular Formula	C₇H₇N₅O₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	121.1ºC
	Symbol	GHS06	Signal Word	Danger

Use of Toxoflavin

Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity[1][2].

Name	1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione
Synonym	More Synonyms

Description	Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity[1][2].
Related Catalog	Research Areas >> Cancer
Target	TCF4/β-catenin[1], KDM4A[2]
In Vitro	Toxoflavin (Xanthothricin) exhibits dose-dependent cytotoxicity against the 3 hepatoma cell lines, and with IC50s of 0.66 μM, 0.36 μM and 0.98 μM for Hep40 cells, HepG2 cells and Huh7 cells respectively[1].
References	[1]. Wei W, et al. Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo. Int J Cancer. 2010 May 15;126(10):2426-36. [2]. Franci G, et al. Identification and characterization of PKF118-310 as a KDM4A inhibitor. Epigenetics. 2017 Mar 4;12(3):198-205.

Density	1.65g/cm3
Boiling Point	276.7ºC at 760 mmHg
Molecular Formula	C₇H₇N₅O₂
Molecular Weight	193.16300
Flash Point	121.1ºC
Exact Mass	193.06000
PSA	82.67000
Index of Refraction	1.76

Toxoflavin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UW7875000

CHEMICAL NAME :: Pyrimido(5,4-e)-as-triazine-5,7-(1H,6H)-dione, 1,6-dimethyl-

CAS REGISTRY NUMBER :: 84-82-2

BEILSTEIN REFERENCE NO. :: 0021014

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C7-H7-N5-O2

MOLECULAR WEIGHT :: 193.19

WISWESSER LINE NOTATION :: T66 BVNVN GNN JNJ C1 G1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8400 ug/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - hematuria Gastrointestinal - hypermotility, diarrhea Sense Organs and Special Senses (Eye) - lacrimation

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 4,259,1954

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOCEAH Journal of Organic Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1936- Volume(issue)/page/year: 31,900,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1700 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - hematuria

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 4,259,1954

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300
Precautionary Statements	P264-P301 + P310
RIDADR	UN 2811 6.1 / PGIII
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Investigations into the Biosynthesis, Regulation, and Self-Resistance of Toxoflavin in Pseudomonas protegens Pf-5.

ChemBioChem. 16 , 1782-90, (2015)

Pseudomonas spp. are prolific producers of natural products from many structural classes. Here we show that the soil bacterium Pseudomonas protegens Pf-5 is capable of producing trace levels of the tr...

The quorum sensing-dependent gene katG of Burkholderia glumae is important for protection from visible light.

J. Bacteriol. 191(13) , 4152-7, (2009)

Quorum sensing (QS) plays important roles in the pathogenicity of Burkholderia glumae, the causative agent of bacterial rice grain rot. We determined how QS is involved in catalase expression in B. gl...

Identification of the product of toxoflavin lyase: degradation via a Baeyer-Villiger oxidation.

J. Am. Chem. Soc. 134(11) , 5326-30, (2012)

Toxoflavin (an azapteridine) is degraded to a single product by toxoflavin lyase (TflA) in a reaction dependent on reductant, Mn(II), and oxygen. The isolated product was fully characterized by NMR an...

Toxoflavin

1,6-Dimethyl-1H-pyrimido[5,4-e][1,2,4]triazin-5,7-dion

1,6-dimethylpyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione

Xanthotricin

Xanthothricin (VAN)

Compound 7215

Toxoflavine

Xanthothricin

1,6-dimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione

GNF-Pf-67

DC Chemicals Limited
China
Product Name: Toxoflavin (PKF118-310)
Price: $500.0/100mg $800.0/250mg $1600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Toxoflavin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Get all suppliers and price by the below link:

Toxoflavin suppliers

Toxoflavin price

Toxoflavin

Use of Toxoflavin

Names

Toxoflavin Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Customs

Articles24

Synonyms