DC Chemicals Limited
China
Product Name: Toxoflavin (PKF118-310)
Price: $500.0/100mg $800.0/250mg $1600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Toxoflavin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

84-82-2

84-82-2 structure

84-82-2 structure

Name: Toxoflavin
Chemical Name: 1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione
CAS Number: 84-82-2
Molecular Formula: C₇H₇N₅O₂
Molecular Weight: 193.16300
Catalog: Natural product Moss
Create Date: 2018-03-01 08:00:00
Modify Date: 2024-01-06 15:35:11
Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity[1][2].

Name	1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione
Synonyms	Toxoflavin 1,6-Dimethyl-1H-pyrimido[5,4-e][1,2,4]triazin-5,7-dion 1,6-dimethylpyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione Xanthotricin Xanthothricin (VAN) Compound 7215 Toxoflavine Xanthothricin 1,6-dimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione GNF-Pf-67

Description	Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity[1][2].
Related Catalog	Research Areas >> Cancer
Target	TCF4/β-catenin[1], KDM4A[2]
In Vitro	Toxoflavin (Xanthothricin) exhibits dose-dependent cytotoxicity against the 3 hepatoma cell lines, and with IC50s of 0.66 μM, 0.36 μM and 0.98 μM for Hep40 cells, HepG2 cells and Huh7 cells respectively[1].
References	[1]. Wei W, et al. Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo. Int J Cancer. 2010 May 15;126(10):2426-36. [2]. Franci G, et al. Identification and characterization of PKF118-310 as a KDM4A inhibitor. Epigenetics. 2017 Mar 4;12(3):198-205.

Density	1.65g/cm3
Boiling Point	276.7ºC at 760 mmHg
Molecular Formula	C₇H₇N₅O₂
Molecular Weight	193.16300
Flash Point	121.1ºC
Exact Mass	193.06000
PSA	82.67000
Index of Refraction	1.76

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UW7875000

CHEMICAL NAME :: Pyrimido(5,4-e)-as-triazine-5,7-(1H,6H)-dione, 1,6-dimethyl-

CAS REGISTRY NUMBER :: 84-82-2

BEILSTEIN REFERENCE NO. :: 0021014

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C7-H7-N5-O2

MOLECULAR WEIGHT :: 193.19

WISWESSER LINE NOTATION :: T66 BVNVN GNN JNJ C1 G1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8400 ug/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - hematuria Gastrointestinal - hypermotility, diarrhea Sense Organs and Special Senses (Eye) - lacrimation

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 4,259,1954

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOCEAH Journal of Organic Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1936- Volume(issue)/page/year: 31,900,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1700 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - hematuria

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 4,259,1954

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300
Precautionary Statements	P264-P301 + P310
RIDADR	UN 2811 6.1 / PGIII
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%