NSC 65346
NSC 65346结构式
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常用名 | NSC 65346 | 英文名 | Sangivamycin |
|---|---|---|---|---|
| CAS号 | 18417-89-5 | 分子量 | 309.28 | |
| 密度 | N/A | 沸点 | 880.6ºC at 760 mmHg | |
| 分子式 | C12H15N5O5 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 486.4ºC | |
| 符号 |
GHS06 |
信号词 | Danger |
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Synthesis and in vitro antitumor activity of some amino-deoxy 7-hexofuranosylpyrrolo[2,3-d]pyrimidines.
Carbohydr. Res. 308(3-4) , 319-28, (1998) 7-(6-amino-6-deoxy-beta-D-glucofuranosyl)-5-cyanopyrrolo[2,3 -d]pyrimidine (22) and 7-(3-amino-methyl-3-deoxy-beta-D-allofuranosyl)-5- cyanopyrrolo[2,3-d]pyrimidine (28) were synthesized by sequentially coupling silylated 4-amino-6-bromo-5- cyanopyrrolo[2,3-d... |
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Kinetics and localization of the phosphorylation of rhodopsin by protein kinase C.
J. Biol. Chem. 270(12) , 6710-7, (1995) Protein kinase C isolated from retina catalyzes the stoichiometric phosphorylation of bovine rhodopsin. Enzymological studies using receptor in rod outer segment membranes stripped of peripheral proteins reveal that the phosphorylation is independent of recep... |
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Synthesis of pyrrolo[2,1-f][1,2,4]triazine C-nucleosides. Isosteres of sangivamycin, tubercidin, and toyocamycin.
Carbohydr. Res. 331(1) , 77-82, (2001) Syntheses of pyrrolo[2,1-f][1,2,4]triazine C-nucleosides are reported. Treatment of pyranulose glycoside with aminoguanidine in acetic acid gave the corresponding semicarbazone in 96% yield. The ring transformation of the semicarbazone in dioxane afforded a 5... |
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Shape changes and chemokinesis of Walker carcinosarcoma cells: effects of protein kinase inhibitors (HA-1004, polymyxin B, sangivamycin and tamoxifen) and an inhibitor of diacylglycerol kinase (R 59022).
Anticancer Res. 13(2) , 347-54, (1993) Previous work has shown that PMA and diacylglycerols, activators of protein kinase C (PKC) can suppress cell polarity and locomotor activity of Walker carcinosarcoma cells in vitro, suggesting that PKC activation may result in a stop signal for tumor cell loc... |
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Sangivamycin-like molecule 6 exhibits potent anti-multiple myeloma activity through inhibition of cyclin-dependent kinase-9.
Mol. Cancer Ther. 11(11) , 2321-30, (2012) Despite significant treatment advances over the past decade, multiple myeloma (MM) remains largely incurable. In this study we found that MM cells were remarkably sensitive to the death-inducing effects of a new class of sangivamycin-like molecules (SLM). A p... |
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Prolonged reversal of morphine tolerance with no reversal of dependence by protein kinase C inhibitors.
Brain Res. 958(1) , 28-35, (2002) The phosphatidylinositol (PI) cascade plays a pivotal role in mediating behavioral tolerance to the antinociceptive effects of morphine. Earlier we reported that antinociceptive tolerance was completely reversed 30 min after the administration of inhibitors o... |
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ARC (NSC 188491) has identical activity to Sangivamycin (NSC 65346) including inhibition of both P-TEFb and PKC.
BMC Cancer 9 , 63, (2009) The nucleoside analog, ARC (NSC 188491) is a recently characterized transcriptional inhibitor that selectively kills cancer cells and has the ability to perturb angiogenesis in vitro. In this study, the mechanism of action of ARC was further investigated by c... |
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Synthesis of 2'-beta-C-methyl toyocamycin and sangivamycin analogues as potential HCV inhibitors.
Bioorg. Med. Chem. Lett. 15(3) , 725-7, (2005) Coupling reaction of 2-beta-C-methyl-1,2,3,4-tetra-O-benzoyl-d-ribofuranose with 4-amino-6-bromo-5-cyanopyrrolo[2,3-d]pyrimidine, followed by debromination and debenzoylation, gave the 2'-beta-C-methyl toyocamycin in high yield. Based on this result, a series... |
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Inhibition of tumor angiogenesis by targeting endothelial surface ATP synthase with sangivamycin.
Jpn. J. Clin. Oncol. 37(11) , 867-73, (2007) Sangivamycin, an antibiotic with anti-tumor and anti-herpes virus activities by inhibiting both DNA/RNA synthesis and protein kinase C activity, was reported to suppress selectively DNA synthesis and growth of human umbilical vein endothelial cells and their ... |
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Distribution and characteristics of Ca+2-phosphatidylserine-dependent protein kinase C in subcellular fractions and lamellar bodies of adult rabbit lung.
Life Sci. 55(14) , 1129-37, (1994) Pulmonary surfactant prevents lung collapse at minimal alveolar diameter. Since surfactant acts extracellularly, secretion is vitally important in regulating the alveolar surfactant levels. Studies with phorbol esters which stimulate protein kinase C (PKC) ac... |