N-α-(2,4-二硝基-5-氟苯基)-L-丙氨酸
N-α-(2,4-二硝基-5-氟苯基)-L-丙氨酸结构式
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常用名 | N-α-(2,4-二硝基-5-氟苯基)-L-丙氨酸 | 英文名 | N2-(5-Fluoro-2,4-dinitrophenyl)-L-alaninamide |
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| CAS号 | 95713-52-3 | 分子量 | 272.190 | |
| 密度 | 1.6±0.1 g/cm3 | 沸点 | 544.5±50.0 °C at 760 mmHg | |
| 分子式 | C9H9FN4O5 | 熔点 | 229ºC | |
| MSDS | 中文版 美版 | 闪点 | 283.1±30.1 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Structural analysis reveals the substrate-binding mechanism for the expanded substrate specificity of mutant meso-diaminopimelate dehydrogenase.
ChemBioChem. 16(6) , 924-9, (2015) A meso-diaminopimelate dehydrogenase (DAPDH) from Clostridium tetani E88 (CtDAPDH) was found to have low activity toward the D-amino acids other than its native substrate. Site-directed mutagenesis similar to that carried out on the residues mutated by Vedha-... |
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Biosynthesis of the new broad-spectrum lipopeptide antibiotic paenibacterin in Paenibacillus thiaminolyticus OSY-SE.
Res. Microbiol. 165(3) , 243-51, (2014) Paenibacterin is a novel lipopeptide antibiotic with potent activity against Gram-negative and Gram-positive human pathogens. The antibiotic consists of a cyclic 13-residue peptide and an N-terminal C₁₅ fatty acyl chain. To elucidate the biosynthesis of paeni... |
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Structure elucidation and biosynthesis of fuscachelins, peptide siderophores from the moderate thermophile Thermobifida fusca.
Proc. Natl. Acad. Sci. U. S. A. 105 , 15311-6, (2008) Bacteria belonging to the order Actinomycetales have proven to be an important source of biologically active and often therapeutically useful natural products. The characterization of orphan biosynthetic gene clusters is an emerging and valuable approach to t... |
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Use of Marfey's reagent and analogs for chiral amino acid analysis: assessment and applications to natural products and biological systems.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(29) , 3148-61, (2011) The present paper describes an updated knowledge and status on Marfey's reagent (MR), 1-fluoro-2,4-dinitrophenyl-5-L-alanine amide (FDNP-L-Ala-NH(2)). The reagent is used for pre-column derivatization of amino acids followed by HPLC separation of the diastere... |
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Chromatographic separation of enantiomers of non-protein alpha-amino acids after derivatization with Marfey's reagent and its four variants.
Amino Acids 36(3) , 571-9, (2009) Some non-protein alpha-amino acids were derivatized with 1-fluoro-2,4-dinitrophenyl-5-L-alaninamide (Marfey's reagent, MR, FDNP-L-Ala-NH(2),) and four of its structural variants FDNP-L-Phe-NH(2), FDNP-L-Val-NH(2), FDNP-L-Leu-NH(2) and FDNP-L-Pro-NH(2). The re... |
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Esterification of 9-fluorenylmethoxycarbonyl-glycosylated serine and cysteine derivatives with an hydroxymethyl resin.
J. Pept. Res. 50(6) , 415-20, (1997) Esterification of glycosylated serine and cysteine derivatives with a 4-alkoxybenzyl alcohol (Wang) resin is described. The classical methods of ester bond formation (symmetrical anhydride, 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate... |
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Quantification of serine enantiomers in rat brain microdialysate using Marfey's reagent and LC/MS/MS.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 846(1-2) , 359-63, (2007) The ability to selectively measure serine enantiomer concentrations in rat brain microdialysate is essential during drug discovery to study the interaction of d-serine with the N-methyl-d-aspartate (NMDA) subtype of the glutamate receptor. NMDA receptor-stimu... |
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Enantiomeric determination of amphetamine and methamphetamine in urine by precolumn derivatization with Marfey's reagent and HPLC.
J. Anal. Toxicol. 22(4) , 265-9, (1998) An analytical method was developed for enantiomeric determination of amphetamine and methamphetamine in human urine. The enantiomers were isolated from urine by solid-phase extraction, and diastereomers were formed by derivatization with the chiral Marfey's r... |
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Indirect resolution of enantiomers of penicillamine by TLC and HPLC using Marfey's reagent and its variants.
Biomed. Chromatogr. 21(10) , 1064-8, (2007) TLC and HPLC methods were developed for indirect chiral separation of penicillamine (3,3-dimethylcysteine) enantiomers after derivatization with Marfey's reagent (FDNP-Ala-NH(2)) and two of its structural variants, FDNP-Phe-NH(2) and FDNP-Val-NH(2). The binar... |
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High-performance liquid chromatographic separation of novel atropic alpha,alpha-disubstituted-beta-amino acids, either on different beta-cyclodextrin-bonded phases or as their 1-fluoro-2,4-dinitrophenyl-5-L-alanine amide derivatives.
J. Chromatogr. A. 846(1-2) , 83-91, (1999) The high-performance liquid chromatographic enantioresolution of free and N- and/or C-protected derivatives of (R,S)-2',1':1,2;1",2":3,4-dinaphthcyclohepta-1,3-diene-6-aminometh yl-6- carboxylic acid (beta 2-Bin) by direct and indirect methods is reported. Th... |