2',7'-二氯荧光素
2',7'-二氯荧光素结构式
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常用名 | 2',7'-二氯荧光素 | 英文名 | dichlorofluorescein |
|---|---|---|---|---|
| CAS号 | 76-54-0 | 分子量 | 401.196 | |
| 密度 | 1.8±0.1 g/cm3 | 沸点 | 634.4±55.0 °C at 760 mmHg | |
| 分子式 | C20H10Cl2O5 | 熔点 | 280 °C (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 337.4±31.5 °C | |
| 符号 |
GHS02, GHS07 |
信号词 | Danger |
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Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line.
Toxicol. In Vitro 29(3) , 417-25, (2015) Plant-derived dietary polyphenolic compounds, such as flavonoids, with cancer cell-specific pro-apoptotic activity and chemopreventive potential are thought to be promising anticancer agents. In the present study, we were interested in determining if flavonoi... |
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SapC-DOPS nanovesicles induce Smac- and Bax-dependent apoptosis through mitochondrial activation in neuroblastomas.
Mol. Cancer 14 , 78, (2015) High toxicity, morbidity and secondary malignancy render chemotherapy of neuroblastoma inefficient, prompting the search for novel compounds. Nanovesicles offer great promise in imaging and treatment of cancer. SapC-DOPS, a stable nanovesicle formed from the ... |
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Luteolin-induced protection of H₂O₂-induced apoptosis in PC12 cells and the associated pathway.
Mol. Med. Report. 12 , 7699-704, (2015) Increasing evidence has indicated that the generation of reactive oxygen species (ROS) contributes to H2O2‑induced nerve injury. This may result in oxidative stress that leads to cell damage or death. Dietary or pharmaceutical augmentation of the endogenous a... |
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Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome.
Proc. Natl. Acad. Sci. U. S. A. 112 , E2910-9, (2015) UV-sensitive syndrome (UV(S)S) and Cockayne syndrome (CS) are human disorders caused by CSA or CSB gene mutations; both conditions cause defective transcription-coupled repair and photosensitivity. Patients with CS also display neurological and developmental ... |
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Photo-protective effect of americanin B against ultraviolet B-induced damage in cultured human keratinocytes.
Environ. Toxicol. Pharmacol. 38(3) , 891-900, (2014) Excessive ultraviolet (UV) radiation, a constituent of sunlight, can induce multiple types of skin damage. We recently demonstrated that americanin B, a lignin compound, protected cells against hydrogen peroxide (H2O2)-induced damage by exerting antioxidant e... |
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Effect of N-n-butyl haloperidol iodide on ROS/JNK/Egr-1 signaling in H9c2 cells after hypoxia/reoxygenation.
Sci. Rep. 5 , 11809, (2015) Reactive oxygen species (ROS)-induced oxidative stress in cells is an important pathophysiological process during myocardial ischemia/reperfusion (I/R) injury, and the transcription factor Egr-1 is a master switch for various damage pathways during reperfusio... |
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Fluorescence and electronic action spectroscopy of mass-selected gas-phase fluorescein, 2',7'-dichlorofluorescein, and 2',7'-difluorofluorescein ions.
J. Phys. Chem. A , (2013) 2',7'-Dichloro- and 2',7'-difluorofluoresceins are superior alternatives to underivatized fluorescein. Although several studies characterizing their condensed-phase photophysical properties have been reported, little is known about their intrinsic characteris... |
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Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity.
J. Med. Chem. 54 , 6936-48, (2011) Iron chelators of the 2'-benzoylpyridine thiosemicarbazone (BpT) class show substantial potential as anticancer agents. To explore structure-activity relationships, new BpT analogues were designed that incorporated halogen substituents on the noncoordinating ... |
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Effects of plant species, stage of maturity, and level of formic acid addition on lipolysis, lipid content, and fatty acid composition during ensiling.
J. Anim. Sci. 93 , 4408-23, (2015) Forage type and management influences the nutritional quality and fatty acid composition of ruminant milk. Replacing grass silage with red clover (RC; L.) silage increases milk fat 18:3-3 concentration. Red clover has a higher polyphenol oxidase (PPO) activit... |
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Astaxanthin from Haematococcus pluvialis Prevents Oxidative Stress on Human Endothelial Cells without Toxicity.
Mar. Drugs 13 , 2857-74, (2015) Astaxanthin, a powerful antioxidant, is a good candidate for the prevention of intracellular oxidative stress. The aim of the study was to compare the antioxidant activity of astaxanthin present in two natural extracts from Haematococcus pluvialis, a microalg... |