3-氨基-2-(4-氯苯基)丙基膦酸
3-氨基-2-(4-氯苯基)丙基膦酸结构式
|
常用名 | 3-氨基-2-(4-氯苯基)丙基膦酸 | 英文名 | PHACLOFEN |
|---|---|---|---|---|
| CAS号 | 114012-12-3 | 分子量 | 249.63100 | |
| 密度 | 1.432 g/cm3 | 沸点 | 467.1ºC at 760 mmHg | |
| 分子式 | C9H13ClNO3P | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 236.3ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
|
PKC-mediated GABAergic enhancement of dopaminergic responses: implication for short-term potentiation at a dual-transmitter synapse.
J. Neurophysiol. 112(1) , 22-9, (2014) Transmitter-mediated homosynaptic potentiation is generally implemented by the same transmitter that mediates the excitatory postsynaptic potentials (EPSPs), e.g., glutamate. When a presynaptic neuron contains more than one transmitter, however, potentiation ... |
|
|
Transcriptome analysis of the key role of GAT2 gene in the hyper-accumulation of copper in the oyster Crassostrea angulata.
Sci. Rep. 5 , 17751, (2015) One paradigm of oysters as the hyper-accumulators of many toxic metals is the inter-individual variation of metals, but the molecular mechanisms remain very elusive. A comprehensive analysis of the transcriptome of Crassostrea angulata was conducted to reveal... |
|
|
The antinociceptive effect of stimulating the retrosplenial cortex in the rat tail-flick test but not in the formalin test involves the rostral anterior cingulate cortex.
Pharmacol. Biochem. Behav. 131 , 112-8, (2015) The stimulation of the retrosplenial cortex (RSC) is antinociceptive in the rat tail-flick and formalin tests. The rat RSC is caudal to and send projections to the ipsilateral anterior cingulate cortex (ACC), which is also involved in pain processing. This st... |
|
|
Effects of Withania somnifera on oral ethanol self-administration in rats.
Behav. Pharmacol. 25(7) , 618-28, (2014) Recent evidence has shown that Withania somnifera Dunal (Ashwagandha or Indian ginseng), a herbal remedy used in traditional medicine, impairs morphine-elicited place conditioning. Here, we investigated the effect of W. somnifera roots extract (WSE) on motiva... |
|
|
GABA modulates baroreflex in the ventral tegmental area in rat.
Synapse 69 , 592-9, (2015) There are some reports demonstrating the cardiovascular functions of the ventral tegmental area (VTA). About 20-30% of the VTA neurons are GABAergic, which might play a role in baroreflex modulation. This study was performed to find the effects of GABA(A), GA... |
|
|
Phaclofen: a peripheral and central baclofen antagonist.
Brain Res. 405 , 150-154, (1987) Phaclofen, the phosphonic acid derivative of baclofen, reversibly antagonized the depression of the cholinergic twitch response of the guinea pig ileum and distal colon by either baclofen or GABA. When administered microelectrophoretically, phaclofen reversib... |
|
|
A physiological role for GABAB receptors in the central nervous system.
Nature 332 , 156-158, (1988) The role of GABA in synaptic transmission in the mammalian central nervous system is more firmly established than for any other neurotransmitter. With virtually every neuron studied, the synaptic action of GABA is mediated by bicuculline-sensitive GABAA recep... |
|
|
Comparison of antagonism by phaclofen of baclofen induced hyperpolarizations and synaptically mediated late hyperpolarizing potentials recorded intracellularly from rat dorsolateral septal neurons.
Neurosci. Lett. 86 , 77-81, (1988) Phaclofen has recently been described as an antagonist to baclofen at both peripheral and central receptors. We have applied phaclofen in known concentrations to an isolated rat brain slice preparation containing the septal nuclei. Our data demonstrate that p... |
|
|
The Role of GABAB Receptors in Morphine Self-Administration.
Int. J. Prev. Med. 4 , 158-64, (2013) There is only little information about the effects of GABA receptors agonist and antagonist on morphine self-administration. Present study was designed to assess role of GABAB receptors in the regulation of morphine-reinforced self-administration.THIS STUDY W... |
|
|
GABAergic activities control spike timing- and frequency-dependent long-term depression at hippocampal excitatory synapses.
Front Synaptic Neurosci 2 , 22, (2011) GABAergic interneuronal network activities in the hippocampus control a variety of neural functions, including learning and memory, by regulating θ and γ oscillations. How these GABAergic activities at pre- and postsynaptic sites of hippocampal CA1 pyramidal ... |