1-甲酰吡咯烷
1-甲酰吡咯烷结构式
|
常用名 | 1-甲酰吡咯烷 | 英文名 | 1-formylpyrrolidine |
|---|---|---|---|---|
| CAS号 | 3760-54-1 | 分子量 | 99.13110 | |
| 密度 | 1.04 g/mL at 25 °C(lit.) | 沸点 | 92-94 °C15 mm Hg(lit.) | |
| 分子式 | C5H9NO | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 203 °F |
|
N-tritylprolinal: an efficient building block for the stereoselective synthesis of proline-derived amino alcohols.
J. Org. Chem. 68(25) , 9747-52, (2003) N-Tritylprolinal (prepared in four steps from l-proline) shows a very high Felkin diastereoselectivity in its reaction with various nucleophiles, leading to a straightforward and highly stereoselective access to syn-proline-derived amino alcohols. |
|
|
Synthesis and inhibitory activity of acyl-peptidyl-prolinalderivatives toward post-proline cleaving enzyme as nootropic agents.
J. Enzym. Inhib. 3(3) , 163-78, (1990) Several prolinal derivatives were synthesized and examined for their inhibitory activity on post-proline cleaving enzymes from Flavobacterium meningosepticum and bovine brain and their possible properties as nootropic agents. Almost all the compounds tested i... |
|
|
Tyrosine hydroxylase deficiency in three Greek patients with a common ancestral mutation.
Mov. Disord 25(8) , 1086-90, (2010) We present the clinical, biochemical, and molecular findings of three Greek patients with tyrosine hydroxylase (TH) deficiency. All patients presented with a severe clinical phenotype characterized by prominent motor delay, infantile parkinsonism, oculogyric ... |
|
|
New potent prolyl endopeptidase inhibitors: synthesis and structure-activity relationships of indan and tetralin derivatives and their analogues.
J. Med. Chem. 37(13) , 2071-8, (1994) New compounds were synthesized by structural modification of 1-[1-(4-phenylbutanoyl)-L-prolyl]-pyrrolidine (SUAM-1221, 1) or 1-[1-(benzyloxycarbonyl)-L-proly]prolinal (Z-Pro-prolinal,2) and were tested for in vitro inhibitory activities against purified proly... |
|
|
Mechanistic implications of the inhibition of peptidases by amino aldehydes and bestatin.
Biochim. Biophys. Acta 829(3) , 311-8, (1985) alpha-Amino aldehydes and bestatin are found to be effective inhibitors of a cytosolic dipeptidase (rat testicular peptidase C), and a cytosolic tripeptidase (rat kidney peptidase B, EC 3.4.11.4), as well as cytosolic leucine aminopeptidase (pig kidney peptid... |
|
|
Secreted trypanosome cyclophilin inactivates lytic insect defense peptides and induces parasite calcineurin activation and infectivity.
J. Biol. Chem. 288(12) , 8772-84, (2013) The mechanisms by which Trypanosoma cruzi survives antimicrobial peptides and differentiates during its transit through the gastrointestinal tract of the reduviid vector are unknown. We show that cyclophilin, a peptidyl-prolyl isomerase secreted from T. cruzi... |
|
|
Comparison of inhibitory effects of prolinal-containing peptide derivatives on prolyl endopeptidases from bovine brain and Flavobacterium.
J. Biochem. 98(4) , 975-9, (1985) The inhibitory effects of proline-containing peptides and their derivatives on prolyl endopeptidases from Flavobacterium meningosepticum and bovine brain were compared. Replacement of the carboxyl terminal proline in N-blocked peptides with prolinal resulted ... |
|
|
Synthesis and alpha4beta2 nicotinic affinity of 2-pyrrolidinylmethoxyimines and prolinal oxime ethers.
Bioorg. Med. Chem. Lett. 14(23) , 5827-30, (2004) Homochiral E and Z isomers of N-methylprolinal O-isopropyloxime and (1-methyl-2-pyrrolidinyl)methoxyimines were synthesized as candidate bioisosteres of nicotine and its isoxazolic analogue ABT 418. Two of them, namely (S)-2-isopropylideneaminooxymethyl- and ... |
|
|
Radiosynthesis and ex vivo evaluation of [11C]-SIB-1553A as a PET radiotracer for beta4 selective subtype nicotinic acetylcholine receptor.
Nucl. Med. Biol. 35(3) , 377-85, (2008) [11C]-SIB-1553A ((+/-)-4-[2-((N-[11C]-methyl)-2-pyrrolidinyl)ethyl]thiophenol) was labelled with carbon-11 (t1/2=20.4 min) and evaluated in vivo as potential radiotracer for noninvasive assessment of the beta4 subunit nicotinic acetylcholine neurotransmission... |
|
|
[Anti-amnesic effect of prolyl endopeptidase inhibitors in mice].
Nippon. Yakurigaku Zasshi. 89(6) , 323-9, (1987) Based on the results of a previous report that prolyl endopeptidase (PPCE) inhibitors facilitated the acquisition of active avoidance response and retarded the extinction of the response, further studies were made on the effect of PPCE inhibitors on learning ... |