乙琥胺
乙琥胺结构式
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常用名 | 乙琥胺 | 英文名 | Ethosuximide |
|---|---|---|---|---|
| CAS号 | 77-67-8 | 分子量 | 141.168 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 265.3±9.0 °C at 760 mmHg | |
| 分子式 | C7H11NO2 | 熔点 | 51ºC | |
| MSDS | 中文版 美版 | 闪点 | 123.8±18.9 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Ethosuximide and phenytoin dose-dependently attenuate acute nonconvulsive seizures after traumatic brain injury in rats.
J. Neurotrauma 30(23) , 1973-82, (2013) Acute seizures frequently occur following severe traumatic brain injury (TBI) and have been associated with poor patient prognosis. Silent or nonconvulsive seizures (NCS) manifest in the absence of motor convulsion, can only be detected via continuous electro... |
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How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)?
Epilepsia 53 Suppl 8 , 3-11, (2012) Phenobarbital has been in clinical use as an antiepileptic drug (AED) since 1912. The initial clinical success of phenobarbital and other barbiturates affected the design of subsequent AEDs (e.g., phenytoin, primidone, ethosuximide), developed between 1938 an... |
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Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells.
PLoS ONE 9(8) , e104010, (2014) In this study, we aimed to elucidate the effects and mechanism of action of valproic acid on hepatic differentiation from human induced pluripotent stem cell-derived hepatic progenitor cells. Human induced pluripotent stem cells were differentiated into endod... |
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Clinical pharmacokinetics of antiepileptic drugs in paediatric patients. Part I: Phenobarbital, primidone, valproic acid, ethosuximide and mesuximide.
Clin. Pharmacokinet. 29(4) , 257-86, (1995) This article reviews 119 papers published since 1964 on the pharmacokinetics of phenobarbital, primidone, valproic acid, ethosuximide and mesuximide (methsuximide) in paediatric patients. Particular attention has been paid to the role of age in determining th... |
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Heterogeneous effects of antiepileptic drugs in an in vitro epilepsy model--a functional multineuron calcium imaging study.
Eur. J. Neurosci. 42 , 1818-29, (2015) Epilepsy is a chronic brain disease characterised by recurrent seizures. Many studies of this disease have focused on local neuronal activity, such as local field potentials in the brain. In addition, several recent studies have elucidated the collective beha... |
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Interactions between an antidepressant reboxetine and four classic antiepileptic drugs in the mouse model of myoclonic seizures.
Pharmacol. Rep. 67 , 1141-6, (2015) The incidence rate of depression among patients with epilepsy is relatively high. The basis of proper therapy is knowledge of drug interactions, which may enable to maximize therapeutic effects and minimize undesired effects of the combined treatment. The pur... |
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Synthesis and Anticonvulsant Activity of Substituted-1,3-diazaspiro[4.5]decan-4-ones.
Arch. Pharm. (Weinheim) 348 , 575-88, (2015) A series of novel spiroimidazolidinone derivatives 6a-d and 8a-x were synthesized and biologically evaluated for their anticonvulsant activity in the maximal electroshock seizure (MES) assay and the subcutaneous pentylenetetrazole (scPTZ) screening test. Comp... |
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Chronic intrathecal infusion of mibefradil, ethosuximide and nickel attenuates nerve ligation-induced pain in rats.
Br. J. Anaesth. 115 , 105-11, (2015) T-type Ca(2+) channels (TCC) are important for pain transmission, especially the Ca(V)3.2 subtype. In this study, we examined the effects of intrathecal TCC blockers in the L5/6 spinal nerve ligation pain rat model.Under isoflurane anaesthesia, rats received ... |
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Evaluation of longevity enhancing compounds against transactive response DNA-binding protein-43 neuronal toxicity.
Neurobiol. Aging 34(9) , 2175-82, (2013) In simple systems, lifespan can be extended by various methods including dietary restriction, mutations in the insulin/insulin-like growth factor (IGF) pathway or mitochondria among other processes. It is widely held that the mechanisms that extend lifespan m... |
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Quantum dot nanoparticles affect the reproductive system of Caenorhabditis elegans.
Environ. Toxicol. Chem. 31(10) , 2366-74, (2012) Quantum dots (QDs) are an increasingly important class of nanoparticle, but little ecotoxicological data for QDs has been published to date. The effects of mercaptosuccinic acid (MSA)-capped QDs (QDs-MSA) and equivalent concentrations of cadmium (Cd) from cad... |