8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]吡喃
![8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]吡喃结构式](https://image.chemsrc.com/caspic/371/6104-71-8.png)
8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]吡喃结构式
|
常用名 | 8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]吡喃 | 英文名 | N-Desmethylclozapine |
|---|---|---|---|---|
| CAS号 | 6104-71-8 | 分子量 | 312.79700 | |
| 密度 | 1.38g/cm3 | 沸点 | 490.1ºC at 760 mmHg | |
| 分子式 | C17H17ClN4 | 熔点 | 120-125°C | |
| MSDS | 中文版 美版 | 闪点 | 250.2ºC | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
|
Development of a SPE-HPLC-MS/MS method for the determination of most prescribed pharmaceuticals and related metabolites in urban sewage samples.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 990 , 23-30, (2015) Based on regional prescription data several pharmaceuticals with variable amounts of prescription and corresponding metabolites were selected and analyzed in influent and effluent samples of the sewage treatment plant (STP) in Dresden, Germany. Pharmaceutical... |
|
|
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Eur. J. Med. Chem. 46 , 618-30, (2011) A QSAR based predictive model of hERG activity in terms of 'global descriptors' has been developed and evaluated. The QSAR was developed by training 77 compounds covering a wide range of activities and was validated based on an external 'test set' of 80 compo... |
|
|
Functional activation of G-proteins coupled with muscarinic acetylcholine receptors in rat brain membranes.
J. Pharmacol. Sci. 125(2) , 157-68, (2014) The functional activation of Gi/o proteins coupled to muscarinic acetylcholine receptors (mAChRs) was investigated with the conventional guanosine-5'-O-(3-[(35)S]thio) triphosphate ([(35)S]GTPγS) binding assay in rat brain membranes. The most efficacious stim... |
|
|
Toxicological screening of human plasma by on-line SPE-HPLC-DAD: identification and quantification of basic drugs and metabolites.
Biomed. Chromatogr. 29 , 935-52, (2015) An automated multi-analyte screening method for the identification and quantification of 92 drugs and metabolites based on on-line solid-phase extraction-high-performance liquid chromatography-diode array detection technique was developed and successfully val... |
|
|
Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.
J. Med. Chem. 52 , 4266-76, (2009) The cardiac hERG K(+) channel constitutes a long-standing and expensive antitarget for the drug industry. From a study of the flexibility of hERG around its internal binding cavity, we have developed a new structural model of drug binding to hERG, which invol... |
|
|
1-Methyl-4-phenylpyridinium stereotactic infusion completely and specifically ablated the nigrostriatal dopaminergic pathway in rhesus macaque.
PLoS ONE 10 , e0127953, (2015) Complete and specific ablation of a single dopaminergic (DA) pathway is a critical step to distinguish the roles of DA pathways in vivo. However, this kind of technique has not been reported in non-human primates. This study aimed to establish a lesioning met... |
|
|
Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists.
Eur. J. Pharmacol. 245 , 179-182, (1993) The effects of the atypical antipsychotic drug, clozapine, and its two major metabolites in man, N-desmethylclozapine and clozapine N-oxide, on 5-HT1C receptor mediated phosphoinositide hydrolysis were studied in rat choroid plexus. Clozapine and N-desmethylc... |
|
|
Design and synthesis of novel derivatives of the muscarinic agonist tetra(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether (CDD-0304): effects of structural modifications on the binding and activity at muscarinic receptor subtypes and chimeras.
J. Med. Chem. 49 , 7518-31, (2006) As part of a continuing effort to design and synthesize highly selective muscarinic agonists for different muscarinic receptor subtypes, several tetra(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazo... |
|
|
Plasma clozapine and norclozapine in relation to prescribed dose and other factors in patients aged 65 years and over: data from a therapeutic drug monitoring service, 1996-2010.
Hum. Psychopharmacol. Clin. Exp. 27(3) , 277-83, (2012) To investigate the effect of dose and other factors on plasma clozapine concentrations in patients aged 65 years and over.Audit of clozapine therapeutic drug monitoring data, 1996-2010.There were 1930 samples [778 patients, 363 men aged (median, range) 67 (65... |
|
|
Discriminative stimulus properties of N-desmethylclozapine, the major active metabolite of the atypical antipsychotic clozapine, in C57BL/6 mice.
Behav. Pharmacol. 23(3) , 262-70, (2012) N-desmethylclozapine (NDMC) is the major active metabolite of the atypical antipsychotic drug clozapine and may contribute to the therapeutic efficacy of clozapine. Although they share many pharmacological features, it is noteworthy that NDMC is a partial dop... |