N-Desmethylclozapine
Modify Date: 2024-01-02 10:14:38
N-Desmethylclozapine structure
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Common Name | N-Desmethylclozapine | ||
|---|---|---|---|---|
| CAS Number | 6104-71-8 | Molecular Weight | 312.79700 | |
| Density | 1.38g/cm3 | Boiling Point | 490.1ºC at 760 mmHg | |
| Molecular Formula | C17H17ClN4 | Melting Point | 120-125°C | |
| MSDS | Chinese USA | Flash Point | 250.2ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
Use of N-DesmethylclozapineN-Desmethylclozapine is a dengue virus inhibitor, and an agonist of δ-opioid receptor. |
| Name | N-desmethylclozapine |
|---|---|
| Synonym | More Synonyms |
| Description | N-Desmethylclozapine is a dengue virus inhibitor, and an agonist of δ-opioid receptor. |
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| Related Catalog | |
| In Vitro | The IC50s of N-desmethylclozapine, fluoxetine hydrochloride, and salmeterol xinafoate in Huh-7 cells infected with DENV-2 are 1 μM, 0.38 μM, and 0.67 μM, respectively. The levels of NS3 are reduced in cells treated with all three inhibitors compared to DMSO treatment, suggesting that the inhibitors act at a stage prior to viral protein translation. N-Desmethylclozapine-treated cells show a >75% reduction in negative-strand RNA levels[1]. N-desmethylclozapine exhibits slight agonistic effects on the M1 mAChR, and agonistic properties at the 5-HT1A receptor in the cerebral cortex and hippocampus. This compound also behaves as an agonist at the δ-opioid receptor in the cerebral cortex and striatum[2]. N-desmethylclozapine (3 μM) greatly decreases the outward current in excitatory neurons, but not in inhibitory neurons. In excitatory neurons, N-desmethylclozapine alone is more effective than either clozapine alone or the combination of clozapine and N-desmethylclozapine. The effect of N-desmethylclozapine in excitatory neurons is significantly suppressed by 0.1 μM pirenzepine and 1 μM atropine. N-desmethylclozapine, but not clozapine, suppressed K+ channels via M1 receptors in excitatory cells[3]. N-desmethylclozapine leads to a decrease in TxB2 levels under unstimulated conditions as well as under TSST-1 stimulation. Clozapine, N-desmethylclozapine and CPZ possibly act on neurotransmitter systems via modulation of TxA2 or TxB2 production[5]. |
| In Vivo | N-desmethylclozapine in rat and human at M2 and M4 mAChRs underlying presynaptic modulation of GABA and glutamate release, respectively. In particular, N-desmethylclozapine maybe a M2 mAChR antagonist in the rat but has no activity at this receptor in human neocortex. However, N-desmethylclozapine has an agonistic effect at M4 mAChR in the human but no such effect in the rat neocortex[4]. |
| References |
| Density | 1.38g/cm3 |
|---|---|
| Boiling Point | 490.1ºC at 760 mmHg |
| Melting Point | 120-125°C |
| Molecular Formula | C17H17ClN4 |
| Molecular Weight | 312.79700 |
| Flash Point | 250.2ºC |
| Exact Mass | 312.11400 |
| PSA | 39.66000 |
| LogP | 3.22080 |
| Index of Refraction | 1.709 |
| Storage condition | Store at RT |
| Symbol |
GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | 20/22-36/37/38 |
| Safety Phrases | S22-S36-S45 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2933990090 |
![Benzoicacid, 2-[(2-amino-4-chlorophenyl)amino]- structure](https://www.chemsrc.com/caspic/464/67990-66-3.png)
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Development of a SPE-HPLC-MS/MS method for the determination of most prescribed pharmaceuticals and related metabolites in urban sewage samples.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 990 , 23-30, (2015) Based on regional prescription data several pharmaceuticals with variable amounts of prescription and corresponding metabolites were selected and analyzed in influent and effluent samples of the sewag... |
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Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Eur. J. Med. Chem. 46 , 618-30, (2011) A QSAR based predictive model of hERG activity in terms of 'global descriptors' has been developed and evaluated. The QSAR was developed by training 77 compounds covering a wide range of activities an... |
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Functional activation of G-proteins coupled with muscarinic acetylcholine receptors in rat brain membranes.
J. Pharmacol. Sci. 125(2) , 157-68, (2014) The functional activation of Gi/o proteins coupled to muscarinic acetylcholine receptors (mAChRs) was investigated with the conventional guanosine-5'-O-(3-[(35)S]thio) triphosphate ([(35)S]GTPγS) bind... |
| 3-chloro-6-piperazin-1-yl-5H-benzo[b][1,4]benzodiazepine |
| Normethylclozapine |
| BzATP triethylammonium salt |
| Desmethylclozapine |
| EINECS 200-659-6 |
| Demethylclozapine |
| N-Demethylclozapine |
| MFCD00210189 |
| N-desmethyl clozapine |
| Norclozapine |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: N-Desmethylclozapine
- Price: ￥768.0/5mg ￥2688.0/25mg ￥6718.0/100mg
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: N-Desmethylclozapine
- Price: $500.0/100mg $1000.0/250mg $2000.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
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- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: N-desmethylclozapine
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
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