DHFR-IN-2

Modify Date: 2024-01-15 17:05:41

DHFR-IN-2 structure	Common Name	DHFR-IN-2
	CAS Number	331942-46-2	Molecular Weight	227.26
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₃NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of DHFR-IN-2

DHFR-IN-2 (compound 4e) is a potent and uncompetitive inhibitor for MtDHFR (dihydrofolate reductase from M. tuberculosis), with an IC50 of 7 μM. DHFR-IN-2 can be used for tuberculosis (TB) research[1].

Name	DHFR-IN-2

Description	DHFR-IN-2 (compound 4e) is a potent and uncompetitive inhibitor for MtDHFR (dihydrofolate reductase from M. tuberculosis), with an IC50 of 7 μM. DHFR-IN-2 can be used for tuberculosis (TB) research[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> Antifolate
Target	IC50: 7 ± 0.13 μM (MtDHFR)[1]
References	[1]. Kronenberger T,et al. Design, synthesis and biological activity of novel substituted 3-benzoic acid derivatives as MtDHFR inhibitors. Bioorg Med Chem. 2020 Aug 1;28(15):115600.

Molecular Formula	C₁₄H₁₃NO₂
Molecular Weight	227.26