2757991-65-2

2757991-65-2 structure

Name: DHFR-IN-1
Chemical Name: DHFR-IN-1
CAS Number: 2757991-65-2
Molecular Formula: C₂₂H₂₂N₆O₄S₂
Molecular Weight: 498.58
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-09-04 11:59:44
Modify Date: 2025-09-26 21:50:39
DHFR-IN-1 (compound 12) is a potent and selective DHFR (dihydrofolate reductase)inhibitor, with an IC50 of 40.71 nM. DHFR-IN-1 exhibits promising antibacterial activity against gram-positive and gram-negative bacteria. DHFR-IN-1 exhibits moderate antifungal activities. DHFR-IN-1 exhibits a high synergistic effect with Levofloxacin (HY-B0330), where the FIC (fractional inhibitory concentration index) value is 0.249[1].

Name	DHFR-IN-1

Description	DHFR-IN-1 (compound 12) is a potent and selective DHFR (dihydrofolate reductase)inhibitor, with an IC50 of 40.71 nM. DHFR-IN-1 exhibits promising antibacterial activity against gram-positive and gram-negative bacteria. DHFR-IN-1 exhibits moderate antifungal activities. DHFR-IN-1 exhibits a high synergistic effect with Levofloxacin (HY-B0330), where the FIC (fractional inhibitory concentration index) value is 0.249[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 40.71 ± 1.86 nM (DHFR)[1]
References	[1]. Alzahrani AY, et al. Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm activities with molecular modelling study. Bioorg Chem. 2022 Feb;119:105571.

Molecular Formula	C₂₂H₂₂N₆O₄S₂
Molecular Weight	498.58