DHFR-IN-2

Names

[ CAS No. ]:
331942-46-2

[ Name ]:
DHFR-IN-2

Biological Activity

[Description]:

DHFR-IN-2 (compound 4e) is a potent and uncompetitive inhibitor for MtDHFR (dihydrofolate reductase from M. tuberculosis), with an IC50 of 7 μM. DHFR-IN-2 can be used for tuberculosis (TB) research[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> Antifolate

[Target]

IC50: 7 ± 0.13 μM (MtDHFR)[1]


[References]

[1]. Kronenberger T,et al. Design, synthesis and biological activity of novel substituted 3-benzoic acid derivatives as MtDHFR inhibitors. Bioorg Med Chem. 2020 Aug 1;28(15):115600.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H13NO2

[ Molecular Weight ]:
227.26

Related Compounds