KTX-497

Modify Date: 2024-04-09 12:45:14

KTX-497 structure	Common Name	KTX-497
	CAS Number	2432993-46-7	Molecular Weight	854.92
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₅H₄₉F₃N₈O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of KTX-497

KTX-497 is an orally active IRAK4 degrader with a DC50 value of 3 nM. KTX-497 can be used for the research of oncology[1].

Name	KTX-497

Description	KTX-497 is an orally active IRAK4 degrader with a DC50 value of 3 nM. KTX-497 can be used for the research of oncology[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> IRAK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK
Target	IRAK4:3 nM (DC50)
In Vitro	KTX-497 has activity for IRAK4 with a DC50 value of 3 nM[1].
In Vivo	KTX-497 (oral; 10 mg/kg) impacts oral absorption[1]. Animal Model: Rat[1] Dosage: 10 mg/kg Administration: Oral Result: Rat PO PK (10 mg/kg) KTX-497 %F 17 AUC(μM*hr) 1.4
References	[1]. Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications.

Molecular Formula	C₄₅H₄₉F₃N₈O₆
Molecular Weight	854.92