Shanghai Nianxing Industrial Co., Ltd
China
Product Name: KTX-951
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: KTX-951
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

2573298-36-7

2573298-36-7 structure

2573298-36-7 structure

Name: KTX-951
Chemical Name: KTX-951
CAS Number: 2573298-36-7
Molecular Formula: C₄₆H₅₂F₂N₈O₆
Molecular Weight: 850.95
Catalog: Signaling Pathways Immunology/Inflammation IRAK
Create Date: 2022-11-12 13:09:01
Modify Date: 2024-02-04 16:11:09
KTX-951 is an IRAK4 degrader (DC50=18 nM). KTX-951 (10 mg/kg) shows the oral bioavailability (F%) of 22% in a rat model. KTX-951 has good anticancer potential[1].

Name	KTX-951

Description	KTX-951 is an IRAK4 degrader (DC50=18 nM). KTX-951 (10 mg/kg) shows the oral bioavailability (F%) of 22% in a rat model. KTX-951 has good anticancer potential[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> IRAK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK
Target	IRAK4[1].
References	[1]. Walker D H, et al. Degraders targeting both IRAK4 and IMiD substrates show combinatorial effects leading to broader activity with durable and complete regressions in MYD88 mutant lymphoma xenografts in vivo. Cancer Research, 2020, 80(16_Supplement): 5222-5222.

Molecular Formula	C₄₆H₅₂F₂N₈O₆
Molecular Weight	850.95

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