2573302-50-6

2573302-50-6 structure

2573302-50-6 structure

Name: KTX-955
Chemical Name: KTX-955
CAS Number: 2573302-50-6
Molecular Formula: C₄₆H₅₁F₃N₈O₇
Molecular Weight: 884.94
Catalog: Signaling Pathways Immunology/Inflammation IRAK
Create Date: 2022-11-26 20:42:24
Modify Date: 2023-01-17 11:18:01
KTX-955 is a potent IRAK4 degrader with DC50 values of 5 nM and 130 nM for IRAK4 and Ikaros, respectively. KTX-955 can be used to research anticancer[1][2].

Name	KTX-955

Description	KTX-955 is a potent IRAK4 degrader with DC50 values of 5 nM and 130 nM for IRAK4 and Ikaros, respectively. KTX-955 can be used to research anticancer[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> IRAK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK
Target	IRAK4:5 nM (IC50)
In Vitro	KTX-955 (compound I-312) degrades IRAK4 in OCI-LY10 at 24 hours with an IC50 of <0.05 μM[1].
References	[1]. Matthew Weiss. Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications. Northeastern Section, ACS (NESACS). [2]. Nello Mainolfi, et al. Irak degraders and uses thereof. WO2020264499A1

Molecular Formula	C₄₆H₅₁F₃N₈O₇
Molecular Weight	884.94