2573298-14-1

2573298-14-1 structure

2573298-14-1 structure

Name: KTX-612
Chemical Name: KTX-612
CAS Number: 2573298-14-1
Molecular Formula: C₄₆H₅₁F₃N₈O₆
Molecular Weight: 868.94
Catalog: Signaling Pathways Immunology/Inflammation IRAK
Create Date: 2022-11-08 22:07:15
Modify Date: 2024-04-09 10:28:43
KTX-612 is an orally active IRAK4 degrader with a DC50 value of 7 nM. KTX-612 can be used for the research of oncology[1].

Name	KTX-612

Description	KTX-612 is an orally active IRAK4 degrader with a DC50 value of 7 nM. KTX-612 can be used for the research of oncology[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> IRAK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK
Target	IRAK4:7 nM (DC50)
In Vitro	KTX-612 has activity for IRAK4 with a DC50 value of 7 nM[1].
In Vivo	KTX-612 (oral; 10 mg/kg) impacts oral absorption[1]. Animal Model: Rat[1] Dosage: 10 mg/kg Administration: Oral Result: Rat PO PK (10 mg/kg) KTX-612 %F 1 AUC(μM*hr) 0.060
References	[1]. Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications.

Molecular Formula	C₄₆H₅₁F₃N₈O₆
Molecular Weight	868.94