Name | KTX-582 |
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Description | KTX-582 is a potent IRAK4 degrader with DC50 values of 4 nM and 5 nM for IRAK4 and Ikaros, respectively. KTX-582 can induce apoptosis in MYD88MT DLBCL, and is efficient to induce in vivo tumor regressions in lymphoma model[1][2][3]. |
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Related Catalog | |
Target |
DC50: 4 nM (IRAK4), 5 nM (Ikaros)[1] |
In Vitro | KTX-582 (compound I-41) degrades IRAK4 in whole blood monocyte and lymphocyte with IC50s of <0.05 μM[4]. KTX-582 (compound I-41) inhibits IRAK4 in human whole blood LPS TNFα with an IC50 of 0.05~1 μM[4]. |
References |
[3]. Nello Mainolfi, et al. Irak degraders and uses thereof. WO/2020/113233 |
Molecular Formula | C45H51F3N8O7 |
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Molecular Weight | 872.93 |