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2432993-46-7

2432993-46-7 structure
2432993-46-7 structure
  • Name: KTX-497
  • Chemical Name: KTX-497
  • CAS Number: 2432993-46-7
  • Molecular Formula: C45H49F3N8O6
  • Molecular Weight: 854.92
  • Catalog: Signaling Pathways Immunology/Inflammation IRAK
  • Create Date: 2022-11-08 18:33:16
  • Modify Date: 2024-04-09 12:45:14
  • KTX-497 is an orally active IRAK4 degrader with a DC50 value of 3 nM. KTX-497 can be used for the research of oncology[1].
Name KTX-497
Description KTX-497 is an orally active IRAK4 degrader with a DC50 value of 3 nM. KTX-497 can be used for the research of oncology[1].
Related Catalog
Target

IRAK4:3 nM (DC50)

In Vitro KTX-497 has activity for IRAK4 with a DC50 value of 3 nM[1].
In Vivo KTX-497 (oral; 10 mg/kg) impacts oral absorption[1]. Animal Model: Rat[1] Dosage: 10 mg/kg Administration: Oral Result: Rat PO PK (10 mg/kg) KTX-497 %F 17 AUC(μM*hr) 1.4
References

[1]. Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications.

Molecular Formula C45H49F3N8O6
Molecular Weight 854.92

Chemsrc provides CAS#:2432993-46-7 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 2432993-46-7 | Chemsrc address: https://www.chemsrc.com/en/baike/1723058.html

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