Shanghai Nianxing Industrial Co., Ltd
China
Product Name: KTX-497
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: KTX-497
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

2432993-46-7

2432993-46-7 structure

2432993-46-7 structure

Name: KTX-497
Chemical Name: KTX-497
CAS Number: 2432993-46-7
Molecular Formula: C₄₅H₄₉F₃N₈O₆
Molecular Weight: 854.92
Catalog: Signaling Pathways Immunology/Inflammation IRAK
Create Date: 2022-11-08 18:33:16
Modify Date: 2024-04-09 12:45:14
KTX-497 is an orally active IRAK4 degrader with a DC50 value of 3 nM. KTX-497 can be used for the research of oncology[1].

Name	KTX-497

Description	KTX-497 is an orally active IRAK4 degrader with a DC50 value of 3 nM. KTX-497 can be used for the research of oncology[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> IRAK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK
Target	IRAK4:3 nM (DC50)
In Vitro	KTX-497 has activity for IRAK4 with a DC50 value of 3 nM[1].
In Vivo	KTX-497 (oral; 10 mg/kg) impacts oral absorption[1]. Animal Model: Rat[1] Dosage: 10 mg/kg Administration: Oral Result: Rat PO PK (10 mg/kg) KTX-497 %F 17 AUC(μM*hr) 1.4
References	[1]. Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications.

Molecular Formula	C₄₅H₄₉F₃N₈O₆
Molecular Weight	854.92

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