KTX-497

Names

[ CAS No. ]:
2432993-46-7

[ Name ]:
KTX-497

Biological Activity

[Description]:

KTX-497 is an orally active IRAK4 degrader with a DC50 value of 3 nM. KTX-497 can be used for the research of oncology[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> IRAK
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK

[Target]

IRAK4:3 nM (DC50)


[In Vitro]

KTX-497 has activity for IRAK4 with a DC50 value of 3 nM[1].

[In Vivo]

KTX-497 (oral; 10 mg/kg) impacts oral absorption[1]. Animal Model: Rat[1] Dosage: 10 mg/kg Administration: Oral Result: Rat PO PK (10 mg/kg) KTX-497 %F 17 AUC(μM*hr) 1.4

[References]

[1]. Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications.

Chemical & Physical Properties

[ Molecular Formula ]:
C45H49F3N8O6

[ Molecular Weight ]:
854.92

Related Compounds