KTX-951

Names

[ CAS No. ]:
2573298-36-7

[ Name ]:
KTX-951

Biological Activity

[Description]:

KTX-951 is an IRAK4 degrader (DC50=18 nM). KTX-951 (10 mg/kg) shows the oral bioavailability (F%) of 22% in a rat model. KTX-951 has good anticancer potential[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> IRAK
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK

[Target]

IRAK4[1].


[References]

[1]. Walker D H, et al. Degraders targeting both IRAK4 and IMiD substrates show combinatorial effects leading to broader activity with durable and complete regressions in MYD88 mutant lymphoma xenografts in vivo. Cancer Research, 2020, 80(16_Supplement): 5222-5222.

Chemical & Physical Properties

[ Molecular Formula ]:
C46H52F2N8O6

[ Molecular Weight ]:
850.95

Related Compounds