Pantothenate Kinase Inhibitor

Modify Date: 2024-01-14 18:18:39

Pantothenate Kinase Inhibitor Structure
Pantothenate Kinase Inhibitor structure
Common Name Pantothenate Kinase Inhibitor
CAS Number 902614-04-4 Molecular Weight 391.49
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C21H21N5OS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Pantothenate Kinase Inhibitor


Pantothenate kinase-IN-2 is a potent Pantothenate kinase 1/3 (PanK1/3) inhibitor with an IC50 of 0.14 μM and 0.36 μM. Pantothenate kinase-IN-2 is a promising agent for PKAN (PanK-associated neurodegeneration) and diabetes research[1].

 Names

Name Pantothenate Kinase Inhibitor
Synonym More Synonyms

 Pantothenate Kinase Inhibitor Biological Activity

Description Pantothenate kinase-IN-2 is a potent Pantothenate kinase 1/3 (PanK1/3) inhibitor with an IC50 of 0.14 μM and 0.36 μM. Pantothenate kinase-IN-2 is a promising agent for PKAN (PanK-associated neurodegeneration) and diabetes research[1].
Related Catalog
Target

IC50: 0.14 μM (PanK1); 0.36 μM (PanK3)[1]

References

[1]. Lalit Kumar Sharma, et al. A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases. J Med Chem. 2015 Feb 12;58(3):1563-8.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C21H21N5OS
Molecular Weight 391.49
Exact Mass 391.146667
LogP 3.98
Index of Refraction 1.694
Storage condition 2-8°C

 Synonyms

MFCD14776926
3-(2,4-Dimethylpyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidin-3-yl)-N-[3-(methylsulfanyl)phenyl]propanamide
Pantothenate Kinase Inhibitor
Pyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidine-3-propanamide, 2,4-dimethyl-N-[3-(methylthio)phenyl]-