RIP2 kinase inhibitor 1

Modify Date: 2025-08-23 18:46:54

RIP2 kinase inhibitor 1 Structure
RIP2 kinase inhibitor 1 structure
Common Name RIP2 kinase inhibitor 1
CAS Number 2380028-10-2 Molecular Weight 355.41
Density N/A Boiling Point N/A
Molecular Formula C17H17N5O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RIP2 kinase inhibitor 1


RIP2 kinase inhibitor 1 (compound 11) is a potent and selective receptor interacting protein 2 (RIP2) kinase inhibitor with an IC50 of 0.03 μM for RIP2 FP. RIP2 kinase inhibitor 1 is used for autoinflammatory disorders[1].

 Names

Name RIP2 kinase inhibitor 1

 RIP2 kinase inhibitor 1 Biological Activity

Description RIP2 kinase inhibitor 1 (compound 11) is a potent and selective receptor interacting protein 2 (RIP2) kinase inhibitor with an IC50 of 0.03 μM for RIP2 FP. RIP2 kinase inhibitor 1 is used for autoinflammatory disorders[1].
Related Catalog
Target

IC50: 0.03 μM (RIP2)[1]

In Vitro RIP2 kinase inhibitor 1 (compound 11) inhibits human whole blood (hWB; IC50=0.05 μM), activin receptor-like kinase 5 (ALK5; IC50>10 μM), VEGFR2 (IC50=7.94 μM), lymphocyte-specific protein tyrosine kinase (LCK; IC50=31.6 μM)[1].
References

[1]. Haffner CD, et al. Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.ACS Med Chem Lett. 2019 Oct 11;10(11):1518-1523.

 Chemical & Physical Properties

Molecular Formula C17H17N5O2S
Molecular Weight 355.41
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