<Suppliers Price>

RIP2 kinase inhibitor 1

Names

[ CAS No. ]:
2380028-10-2

[ Name ]:
RIP2 kinase inhibitor 1

Biological Activity

[Description]:

RIP2 kinase inhibitor 1 (compound 11) is a potent and selective receptor interacting protein 2 (RIP2) kinase inhibitor with an IC50 of 0.03 μM for RIP2 FP. RIP2 kinase inhibitor 1 is used for autoinflammatory disorders[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> RIP kinase
Research Areas >> Inflammation/Immunology

[Target]

IC50: 0.03 μM (RIP2)[1]


[In Vitro]

RIP2 kinase inhibitor 1 (compound 11) inhibits human whole blood (hWB; IC50=0.05 μM), activin receptor-like kinase 5 (ALK5; IC50>10 μM), VEGFR2 (IC50=7.94 μM), lymphocyte-specific protein tyrosine kinase (LCK; IC50=31.6 μM)[1].

[References]

[1]. Haffner CD, et al. Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.ACS Med Chem Lett. 2019 Oct 11;10(11):1518-1523.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H17N5O2S

[ Molecular Weight ]:
355.41

Related Compounds