PDGFRα kinase inhibitor 1

Modify Date: 2024-01-09 19:27:58

PDGFRα kinase inhibitor 1 structure	Common Name	PDGFRα kinase inhibitor 1
	CAS Number	2209053-93-8	Molecular Weight	586.69
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₄H₃₄N₈O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PDGFRα kinase inhibitor 1

PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC50s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively[1].

Name	PDGFRα kinase inhibitor 1

Description	PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC50s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR
Target	PDGFRα:132 nM (IC50) PDGFRβ:6115 nM (IC50)
In Vitro	PDGFRα kinase inhibitor 1 (CHMFL-PDGFR-159, Compound 15i) exhibits weak inhibition to DDR1 kinase (IC50: 2462±126 nM)[1].
References	[1]. Wang Q, et al. Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFRα kinase inhibitor for PDGFRα driving chronic eosinophilic leukemia. Eur J Med Chem. 2018 Apr 25;150:366-384.

Molecular Formula	C₃₄H₃₄N₈O₂
Molecular Weight	586.69

DC Chemicals Limited
China
Product Name: PDGFRα kinase inhibitor 1
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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