902614-04-4

902614-04-4 structure

Name: Pantothenate Kinase Inhibitor
Chemical Name: Pantothenate Kinase Inhibitor
CAS Number: 902614-04-4
Molecular Formula: C₂₁H₂₁N₅OS
Molecular Weight: 391.49
Catalog: Research Areas Metabolic Disease
Create Date: 2021-08-27 22:03:12
Modify Date: 2024-01-14 18:18:39
Pantothenate kinase-IN-2 is a potent Pantothenate kinase 1/3 (PanK1/3) inhibitor with an IC50 of 0.14 μM and 0.36 μM. Pantothenate kinase-IN-2 is a promising agent for PKAN (PanK-associated neurodegeneration) and diabetes research[1].

Name	Pantothenate Kinase Inhibitor
Synonyms	MFCD14776926 3-(2,4-Dimethylpyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidin-3-yl)-N-[3-(methylsulfanyl)phenyl]propanamide Pantothenate Kinase Inhibitor Pyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidine-3-propanamide, 2,4-dimethyl-N-[3-(methylthio)phenyl]-

Description	Pantothenate kinase-IN-2 is a potent Pantothenate kinase 1/3 (PanK1/3) inhibitor with an IC50 of 0.14 μM and 0.36 μM. Pantothenate kinase-IN-2 is a promising agent for PKAN (PanK-associated neurodegeneration) and diabetes research[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	IC50: 0.14 μM (PanK1); 0.36 μM (PanK3)[1]
References	[1]. Lalit Kumar Sharma, et al. A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases. J Med Chem. 2015 Feb 12;58(3):1563-8.