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2417228-90-9

2417228-90-9 structure

2417228-90-9 structure

Name: Aurora kinase inhibitor-10
Chemical Name: Aurora kinase inhibitor-10
CAS Number: 2417228-90-9
Molecular Formula: C₂₁H₁₉F₅N₆O₄S
Molecular Weight: 546.47
Catalog: Signaling Pathways Cell Cycle/DNA Damage Aurora Kinase
Create Date: 2022-09-02 20:14:22
Modify Date: 2025-10-09 23:38:12
Aurora kinase inhibitor-10 (Compound 6c) is an orally active Aurora B inhibitor with an IC50 of 8 nM. Aurora kinase inhibitor-10 shows antitumor activity[1].

Name	Aurora kinase inhibitor-10

Description	Aurora kinase inhibitor-10 (Compound 6c) is an orally active Aurora B inhibitor with an IC50 of 8 nM. Aurora kinase inhibitor-10 shows antitumor activity[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Aurora Kinase Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase
Target	Aurora B:8 nM (IC50)
In Vitro	Aurora kinase inhibitor-10 (Compound 6c) shows antiproliferation activity with IC50 values of 0.57 ± 0.23, 0.42 ± 0.20, 0.69 ± 0.30, 3.97 ± 0.67 and 1.53 ± 0.52 µM against MCF-7, MDA-MB 231, SkoV3, A375 and A549, respectively[1].
References	[1]. Tamizharasan N, et al. Discovery and optimization of novel phenyldiazepine and pyridodiazepine based Aurora kinase inhibitors. Bioorg Chem. 2020 Jun;99:103800.

Molecular Formula	C₂₁H₁₉F₅N₆O₄S
Molecular Weight	546.47

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