Tie2 kinase inhibitor
Modify Date: 2025-08-27 10:49:56
Tie2 kinase inhibitor structure
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Common Name | Tie2 kinase inhibitor | ||
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| CAS Number | 948557-43-5 | Molecular Weight | 439.529 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 699.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C26H21N3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 377.0±31.5 °C | |
Use of Tie2 kinase inhibitorTie2 kinase inhibitor 1 (compound 5) is a potent, selective Tie2 kinase inhibitor with an IC50 of 250 nM[1]. Tie2 kinase inhibitor 1 has anti-cancer activity[2]. |
| Name | 4-[4-(6-methoxynaphthalen-2-yl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine |
|---|---|
| Synonym | More Synonyms |
| Description | Tie2 kinase inhibitor 1 (compound 5) is a potent, selective Tie2 kinase inhibitor with an IC50 of 250 nM[1]. Tie2 kinase inhibitor 1 has anti-cancer activity[2]. |
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| Related Catalog | |
| Target |
IC50: 250 nM (Tie2)[1] |
| In Vitro | Tie2 kinase inhibitor 1 (compound 5) has an IC50 of 50 μM for p38 and has moderate to excellent cellular activities (cell IC50=232 nM)[1]. Tie2 kinase inhibitor 1 inhibits tunica internal endothelial cell kinase 2 (Tie2)[2]. |
| In Vivo | Tie2 kinase inhibitor 1 (intraperitoneally; 50 mg/kg; twice a week for 6 weeks) results in statistically significant reductions in tumor volume by day 15. Tie2 kinase inhibitor 1 results in a 61% reduction in tumor volume by day 20, and reduces tumor volume by 45% by 6 weeks[1]. Animal Model: Athymic nude mice (6- to 8-week-old females)[1] Dosage: 50 mg/kg Administration: Intraperitoneally; twice a week for 6 weeks Result: Resulted in statistically significant reductions in tumor volume. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 699.8±55.0 °C at 760 mmHg |
| Molecular Formula | C26H21N3O2S |
| Molecular Weight | 439.529 |
| Flash Point | 377.0±31.5 °C |
| Exact Mass | 439.135437 |
| PSA | 87.08000 |
| LogP | 5.31 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.746 |
| Storage condition | -20℃ |
| Hazard Codes | N |
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| S1577_Selleck |
| X7496 |
| 4-{4-(6-Methoxy-2-naphthyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine |
| Tie2 kinase inhibitor-Supplied by Selleck Chemicals |
| 4-{4-(6-methoxynaphthalen-2-yl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine |
| Pyridine, 4-[4-(6-methoxy-2-naphthalenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]- |
| Tie2 kinase inhibitor |