m-PEG3-Amine

Modify Date: 2024-01-02 20:00:18

m-PEG3-Amine Structure
m-PEG3-Amine structure
Common Name m-PEG3-Amine
CAS Number 74654-07-2 Molecular Weight 163.21500
Density 0.978g/cm3 Boiling Point 223.9ºC at 760 mmHg
Molecular Formula C7H17NO3 Melting Point N/A
MSDS N/A Flash Point 86.1ºC

 Use of m-PEG3-Amine


m-PEG3-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

 Names

Name 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine
Synonym More Synonyms

 m-PEG3-Amine Biological Activity

Description m-PEG3-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog
Target

Cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References

[1]. Nianhe Han, et al. The derivant of aplysiatoxin 10 and application thereof. CN106279352A.

 Chemical & Physical Properties

Density 0.978g/cm3
Boiling Point 223.9ºC at 760 mmHg
Molecular Formula C7H17NO3
Molecular Weight 163.21500
Flash Point 86.1ºC
Exact Mass 163.12100
PSA 53.71000
LogP 0.32500
Index of Refraction 1.431
Storage condition 2-8°C

 Safety Information

Hazard Codes Xi
HS Code 2922199090

 Synthetic Route

~85%

m-PEG3-Amine Structure

m-PEG3-Amine

CAS#:74654-07-2

Literature: Lowicki, Daniel; Huczynski, Adam; Brzezinski, Bogumil; Bartl, Franz Journal of Molecular Structure, 2011 , vol. 990, # 1-3 p. 121 - 131

~98%

m-PEG3-Amine Structure

m-PEG3-Amine

CAS#:74654-07-2

Literature: Schmidt, Manfred; Amstutz, Rene; Crass, Gerhard; Seebach, Dieter Chemische Berichte, 1980 , vol. 113, # 5 p. 1691 - 1707

~81%

m-PEG3-Amine Structure

m-PEG3-Amine

CAS#:74654-07-2

Literature: Clerc, Jerome; Schellenberg, Barbara; Groll, Michael; Bachmann, Andre S.; Huber, Robert; Dudler, Robert; Kaiser, Markus European Journal of Organic Chemistry, 2010 , # 21 p. 3991 - 4003

~%

m-PEG3-Amine Structure

m-PEG3-Amine

CAS#:74654-07-2

Literature: Samudrala, Ramakrishna; Zhang, Xu; Wadkins, Randy M.; Mattern, Daniell Lewis Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 1 p. 186 - 193

~%

m-PEG3-Amine Structure

m-PEG3-Amine

CAS#:74654-07-2

Literature: Schmidt, Manfred; Amstutz, Rene; Crass, Gerhard; Seebach, Dieter Chemische Berichte, 1980 , vol. 113, # 5 p. 1691 - 1707

~%

m-PEG3-Amine Structure

m-PEG3-Amine

CAS#:74654-07-2

Literature: Heimann,U. et al. Chemische Berichte, 1979 , vol. 112, p. 1392 - 1399

~%

m-PEG3-Amine Structure

m-PEG3-Amine

CAS#:74654-07-2

Literature: Tuchscherer, Andre; Schaarschmidt, Dieter; Schulze, Steffen; Hietschold, Michael; Lang, Heinrich European Journal of Inorganic Chemistry, 2011 , # 28 p. 4421 - 4428

 Customs

HS Code 2922199090
Summary 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

2-[2-(2-methoxyethoxy)ethoxy]ethanamine
2-[2-(2-methoxyethoxy)ethoxy]ethylamine
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