Akt Inhibitor IV
Akt Inhibitor IV structure
|
Common Name | Akt Inhibitor IV | ||
|---|---|---|---|---|
| CAS Number | 681281-88-9 | Molecular Weight | 614.54 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H27IN4S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of Akt Inhibitor IVAkt inhibitor-IV (AKTIV) acts as a PI3K-Akt inhibitor at the E isomer (HY-14971), with potent cytotoxicity[1]. |
| Name | 6-benzothiazol-2-yl-1-ethyl-2-[2-(methyl-phenyl-amino)-vinyl]-3-phenyl-3H-benzoimidazol-1-ium iodide |
|---|---|
| Synonym | More Synonyms |
| Description | Akt inhibitor-IV (AKTIV) acts as a PI3K-Akt inhibitor at the E isomer (HY-14971), with potent cytotoxicity[1]. |
|---|---|
| Related Catalog | |
| References |
| Molecular Formula | C31H27IN4S |
|---|---|
| Molecular Weight | 614.54 |
| Exact Mass | 614.10000 |
| PSA | 53.18000 |
| LogP | 8.31990 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| RIDADR | NONH for all modes of transport |
|
~88%
Akt Inhibitor IV CAS#:681281-88-9 |
| Literature: Sun, Qi; Wu, Runzhi; Cai, Sutang; Lin, Yuan; Sellers, Llewlyn; Sakamoto, Kaori; He, Biao; Peterson, Blake R. Journal of Medicinal Chemistry, 2011 , vol. 54, # 5 p. 1126 - 1139 |
|
~%
Akt Inhibitor IV CAS#:681281-88-9 |
| Literature: Journal of Medicinal Chemistry, , vol. 54, # 5 p. 1126 - 1139 |
|
~%
Akt Inhibitor IV CAS#:681281-88-9 |
| Literature: Journal of Medicinal Chemistry, , vol. 54, # 5 p. 1126 - 1139 |
|
~%
Akt Inhibitor IV CAS#:681281-88-9 |
| Literature: Journal of Medicinal Chemistry, , vol. 54, # 5 p. 1126 - 1139 |
|
~%
Akt Inhibitor IV CAS#:681281-88-9 |
| Literature: Journal of Medicinal Chemistry, , vol. 54, # 5 p. 1126 - 1139 |
|
~%
Akt Inhibitor IV CAS#:681281-88-9 |
| Literature: Journal of Medicinal Chemistry, , vol. 54, # 5 p. 1126 - 1139 |
|
~%
Akt Inhibitor IV CAS#:681281-88-9 |
| Literature: Journal of Medicinal Chemistry, , vol. 54, # 5 p. 1126 - 1139 |
![[(E)-2-(5-benzothiazol-2-yl-1-phenyl-1H-benzoimidazol-2-yl)ethenyl]methyl phenylamine structure](https://image.chemsrc.com/caspic/458/1268527-46-3.png)
![4-(benzo[d]thiazol-2-yl)-N1-phenylbenzene-1,2-diamine structure](https://www.chemsrc.com/extcaspic/496/1268527-45-2.png)
|
Nuclear orphan receptor TLX induces Oct-3/4 for the survival and maintenance of adult hippocampal progenitors upon hypoxia.
J. Thorac. Cardiovasc. Surg. 286 , 9393-404, (2011) Hypoxia promotes neural stem cell proliferation, the mechanism of which is poorly understood. Here, we have identified the nuclear orphan receptor TLX as a mediator for proliferation and pluripotency ... |
|
|
Akt signaling pathway: a target for radiosensitizing human malignant glioma.
Neuro. Oncol. 12 , 434-43, (2010) Radiation therapy plays a central role in the treatment of glioblastoma, but it is not curative due to the high tumor radioresistance. Phosphatidyl-inositol 3-kinase/protein kinase B (Akt) and Janus k... |
| 5-(2-benzothiazolyl)-3-ethyl-2-[2-(methylphenylamino)ethenyl]-1-phenyl-1h-benzimidazolium iodide |
| akt inhibitor iv |